The synthesis of diverse benzazepinoindoles via gold-catalyzed post-Ugi alkyne hydroarylation/Michael addition sequence

Chao Liu; Luc Van Meervelt; Vsevolod A. Peshkov; Erik V. Van der Eycken

doi:10.1039/d2qo00810f

The synthesis of diverse benzazepinoindoles via gold-catalyzed post-Ugi alkyne hydroarylation/Michael addition sequence

Chao Liu
, Luc Van Meervelt
, Vsevolod A. Peshkov
, Erik V. Van der Eycken

KU Leuven
College of Chemistry
Soochow University
People's Friendship University of Russia

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

We have developed a novel gold-catalyzed hydroarylation/Michael addition process, enabling the construction of the benzazepinoindole polycyclic scaffold in a highly efficient manner starting from readily accessible multifunctional Ugi adducts. The developed methodology is characterized by a broad substrate scope, excellent functional-group tolerance and high yields of the target benzazepinoindoles.

Original language	English
Pages (from-to)	4619-4624
Number of pages	6
Journal	Organic Chemistry Frontiers
Volume	9
Issue number	17
DOIs	https://doi.org/10.1039/d2qo00810f
Publication status	Published - Jul 14 2022

ASJC Scopus subject areas

Organic Chemistry

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10.1039/d2qo00810f

THE SYNTHESIS OF DIVERSE BENZAZEPINOINDOLES VIA GOLD-CATALYZED POST-UGI ALKYNE HYDROARYLATION MICHAEL ADDITION SEQUENCEFinal published version, 1.14 MB

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abstract = "We have developed a novel gold-catalyzed hydroarylation/Michael addition process, enabling the construction of the benzazepinoindole polycyclic scaffold in a highly efficient manner starting from readily accessible multifunctional Ugi adducts. The developed methodology is characterized by a broad substrate scope, excellent functional-group tolerance and high yields of the target benzazepinoindoles.",

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AU - Liu, Chao

AU - Van Meervelt, Luc

AU - Peshkov, Vsevolod A.

AU - Van der Eycken, Erik V.

PY - 2022/7/14

Y1 - 2022/7/14

N2 - We have developed a novel gold-catalyzed hydroarylation/Michael addition process, enabling the construction of the benzazepinoindole polycyclic scaffold in a highly efficient manner starting from readily accessible multifunctional Ugi adducts. The developed methodology is characterized by a broad substrate scope, excellent functional-group tolerance and high yields of the target benzazepinoindoles.

AB - We have developed a novel gold-catalyzed hydroarylation/Michael addition process, enabling the construction of the benzazepinoindole polycyclic scaffold in a highly efficient manner starting from readily accessible multifunctional Ugi adducts. The developed methodology is characterized by a broad substrate scope, excellent functional-group tolerance and high yields of the target benzazepinoindoles.

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UR - https://www.scopus.com/pages/publications/85134792719#tab=citedBy

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ER -

The synthesis of diverse benzazepinoindoles via gold-catalyzed post-Ugi alkyne hydroarylation/Michael addition sequence

Abstract

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