TY - JOUR
T1 - Thermometry during MR-guided focused ultrasound in a preclinical model based on thiel embalmed tissue
AU - Karakitsios, Ioannis
AU - Bobeica, Mariana
AU - Saliev, Timur
AU - Rube, Martin
AU - Melzer, Andreas
N1 - Funding Information:
The authors are thankful for financial assistance provided by the project FUSIMO (“Patient specific modelling and simulation of focused ultrasound in moving organs”) funded under the EU’s Seventh Framework Programme for Research and Technological Development. We would also like to thank Dr. Roos Eisma from CAHID project and Mrs. Helen McLeod for providing us with Thiel embalmed human tissue.
Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.
PY - 2014
Y1 - 2014
N2 - Background: The purpose of this work was to determine the accuracy of Proton Resonance Frequency (PRF) thermometry during MR-guided Focused Ultrasound (MRgFUS) ablation on explanted Thiel embalmed human and animal liver, fresh animal liver, and compared to gel phantom. Material and methods: PRF thermometry during MRgFUS was conducted using a 1.5T MRI system. The phantom and the organs were sonicated with the following energies:300J, 600J, 1000J and 1400J. The temperature increase which was measured using PRF thermometry during sonication was compared to actual temperature rise in the same conditions measured by fibre optic thermocouple. Results: Sonication of fresh animal liver showed temperature differences varying between 0.27°C and 0.40°C, whereas the phantom results showed temperature differences from 0.23°C to 0.40°C. For the Thiel embalmed organs, the temperature difference varied from 1.17 °C to 3.13°C for the ovine liver, and from 1.3°C to 3.10°C for the human liver. Conclusion: The temperature differences measured in the fresh liver were small and similar to those found for the gel phantom. However, the temperature differences calculated for the Thiel embalmed organs were higher compared to the fresh organ. This indicates that the PRF-based temperature calibration of the Focused Ultrasound machine for Thiel embalmed tissue is necessary.
AB - Background: The purpose of this work was to determine the accuracy of Proton Resonance Frequency (PRF) thermometry during MR-guided Focused Ultrasound (MRgFUS) ablation on explanted Thiel embalmed human and animal liver, fresh animal liver, and compared to gel phantom. Material and methods: PRF thermometry during MRgFUS was conducted using a 1.5T MRI system. The phantom and the organs were sonicated with the following energies:300J, 600J, 1000J and 1400J. The temperature increase which was measured using PRF thermometry during sonication was compared to actual temperature rise in the same conditions measured by fibre optic thermocouple. Results: Sonication of fresh animal liver showed temperature differences varying between 0.27°C and 0.40°C, whereas the phantom results showed temperature differences from 0.23°C to 0.40°C. For the Thiel embalmed organs, the temperature difference varied from 1.17 °C to 3.13°C for the ovine liver, and from 1.3°C to 3.10°C for the human liver. Conclusion: The temperature differences measured in the fresh liver were small and similar to those found for the gel phantom. However, the temperature differences calculated for the Thiel embalmed organs were higher compared to the fresh organ. This indicates that the PRF-based temperature calibration of the Focused Ultrasound machine for Thiel embalmed tissue is necessary.
KW - MR-guided focused ultrasound
KW - PRF MR thermometry
KW - Thiel embalmed tissue
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U2 - 10.3109/13645706.2013.839950
DO - 10.3109/13645706.2013.839950
M3 - Article
C2 - 24079349
AN - SCOPUS:84899021569
VL - 23
SP - 120
EP - 126
JO - Minimally Invasive Therapy and Allied Technologies
JF - Minimally Invasive Therapy and Allied Technologies
SN - 1364-5706
IS - 2
ER -