Three-component reaction of a 2-aminoazine, a 2-oxoaldehyde, and a cyclic 1,3-dicarbonyl compound for the synthesis of imidazo[1,2- a ]azine derivatives

Vsevolod A. Peshkov, Anatoly A. Peshkov, Olga P. Pereshivko, Kristof Van Hecke, Lali L. Zamigaylo, Erik V. Van Der Eycken, Nikolay Yu Gorobets

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

A three-component reaction of a 2-aminoazine, a 2-oxoaldehyde, and a cyclic 1,3-dicarbonyl compound providing access toward a novel class of imidazo[1,2-a]azine derivatives was developed and studied. The scope of the process was thoroughly explored under three different reaction conditions resulting in the generation of a small library of title compounds and highlighting the possibility of case-specific approach.

Original languageEnglish
Pages (from-to)535-542
Number of pages8
JournalACS Combinatorial Science
Volume16
Issue number10
DOIs
Publication statusPublished - Oct 13 2014
Externally publishedYes

Keywords

  • 1,3-dicarbonyl compounds
  • 2-aminoazines
  • 2-oxoaldehydes
  • imidazo[1,2- a ]azines
  • multicomponent reactions

ASJC Scopus subject areas

  • Chemistry(all)

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