Three-component reaction of a 2-aminoazine, a 2-oxoaldehyde, and a cyclic 1,3-dicarbonyl compound for the synthesis of imidazo[1,2- a ]azine derivatives

Vsevolod A. Peshkov; Anatoly A. Peshkov; Olga P. Pereshivko; Kristof Van Hecke; Lali L. Zamigaylo; Erik V. Van Der Eycken; Nikolay Yu Gorobets

doi:10.1021/co5000695

Three-component reaction of a 2-aminoazine, a 2-oxoaldehyde, and a cyclic 1,3-dicarbonyl compound for the synthesis of imidazo[1,2- a ]azine derivatives

Vsevolod A. Peshkov, Anatoly A. Peshkov, Olga P. Pereshivko, Kristof Van Hecke, Lali L. Zamigaylo, Erik V. Van Der Eycken, Nikolay Yu Gorobets

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

A three-component reaction of a 2-aminoazine, a 2-oxoaldehyde, and a cyclic 1,3-dicarbonyl compound providing access toward a novel class of imidazo[1,2-a]azine derivatives was developed and studied. The scope of the process was thoroughly explored under three different reaction conditions resulting in the generation of a small library of title compounds and highlighting the possibility of case-specific approach.

Original language	English
Pages (from-to)	535-542
Number of pages	8
Journal	ACS Combinatorial Science
Volume	16
Issue number	10
DOIs	https://doi.org/10.1021/co5000695
Publication status	Published - Oct 13 2014
Externally published	Yes

Keywords

1,3-dicarbonyl compounds
2-aminoazines
2-oxoaldehydes
imidazo[1,2- a ]azines
multicomponent reactions

ASJC Scopus subject areas

Chemistry(all)

Access to Document

10.1021/co5000695

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Three-component reaction of a 2-aminoazine, a 2-oxoaldehyde, and a cyclic 1,3-dicarbonyl compound for the synthesis of imidazo[1,2- a ]azine derivatives. / Peshkov, Vsevolod A.; Peshkov, Anatoly A.; Pereshivko, Olga P.; Van Hecke, Kristof; Zamigaylo, Lali L.; Van Der Eycken, Erik V.; Gorobets, Nikolay Yu.

In: ACS Combinatorial Science, Vol. 16, No. 10, 13.10.2014, p. 535-542.

Research output: Contribution to journal › Article › peer-review

Peshkov, Vsevolod A. ; Peshkov, Anatoly A. ; Pereshivko, Olga P. ; Van Hecke, Kristof ; Zamigaylo, Lali L. ; Van Der Eycken, Erik V. ; Gorobets, Nikolay Yu. / Three-component reaction of a 2-aminoazine, a 2-oxoaldehyde, and a cyclic 1,3-dicarbonyl compound for the synthesis of imidazo[1,2- a ]azine derivatives. In: ACS Combinatorial Science. 2014 ; Vol. 16, No. 10. pp. 535-542.

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AU - Van Hecke, Kristof

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