TY - JOUR
T1 - Thrombotic thrombocytopenic purpura secondary to ABO group incompatible blood transfusion in a patient after cardiac surgery
AU - Solak, Yalcin
AU - Selcuk, Nedim Yilmaz
AU - Gaipov, Abduzhappar
AU - Ucar, Ramazan
AU - Biyik, Zeynep
AU - Acar, Kadir
N1 - Copyright:
Copyright 2013 Elsevier B.V., All rights reserved.
PY - 2013/7/1
Y1 - 2013/7/1
N2 - The triggers of secondary thrombotic thrombopcytopenic purpura (TTP) include drug toxicity, radiation and high-dose chemotherapy, angioinvasive infections, surgery and acute graft versus host disease. TTP secondary to surgery have been reported in a number of cases. Most of the cases have been occurred after open heart surgery. Extensive endothelial damage is held responsible as the initiating mechanism in postoperative TTP cases. However, there is no report of secondary TTP describing development owing to ABO incompatible blood transfusion. Here, we describe a patient who developed TTP after transfusion of ABO incompatible blood during hospitalization for bypass surgery. We also propose a hypothesis which may account for the possible underlying mechanism.
AB - The triggers of secondary thrombotic thrombopcytopenic purpura (TTP) include drug toxicity, radiation and high-dose chemotherapy, angioinvasive infections, surgery and acute graft versus host disease. TTP secondary to surgery have been reported in a number of cases. Most of the cases have been occurred after open heart surgery. Extensive endothelial damage is held responsible as the initiating mechanism in postoperative TTP cases. However, there is no report of secondary TTP describing development owing to ABO incompatible blood transfusion. Here, we describe a patient who developed TTP after transfusion of ABO incompatible blood during hospitalization for bypass surgery. We also propose a hypothesis which may account for the possible underlying mechanism.
KW - ABO incompatible
KW - blood transfusion
KW - coronary artery bypass grafting surgery
KW - thrombotic thrombocytopenic purpura
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U2 - 10.4103/0972-5229.118440
DO - 10.4103/0972-5229.118440
M3 - Article
AN - SCOPUS:84885640688
VL - 17
SP - 234
EP - 236
JO - Indian Journal of Critical Care Medicine
JF - Indian Journal of Critical Care Medicine
SN - 0972-5229
IS - 4
ER -