Thyroid multifocal granulomatous folliculitis (palpation thyroiditis)

An immunocytochemical study

H. Ruben Harach, Bharat Jasani

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

We analyzed lymphoid cell populations from thyroid multifocal granulomatous folliculitis (palpation thyroiditis) with a panel of antibodies in order to assess the nature of the immunologic process underlying this otherwise clinically insignificant condition as compared with other specific types of thyroiditis. In general, T lymphocytes predominated over B lymphocytes as shown by the extent of the staining with UCHL-1 (CD45RO or CD3 and L26 (CD20) antibodies, respectively. The ratio of kappa-to-lambda-containing plasma cells was 1.4 to 1. Histiocytes, macrophages, and multinucleate giant cells were all found to stain consistently strongly with KPI (CD68) and, when intraluminal, not infrequently also for thyroglobulin, probaby due to colloid phagocytosis. The differing patterns of light chain restriction observed in multifocal granulomatous folliculitis as compared with Riedel's thyroiditis and Graves disease thyroiditis, for instance, may reflect differences in the nature of the underlying immune response.

Original languageEnglish
Pages (from-to)105-109
Number of pages5
JournalEndocrine Pathology
Volume4
Issue number2
DOIs
Publication statusPublished - Jun 1993
Externally publishedYes

Fingerprint

Folliculitis
Thyroiditis
Palpation
Thyroid Gland
Histiocytes
Antibodies
Thyroglobulin
Graves Disease
Colloids
Giant Cells
Plasma Cells
Phagocytosis
B-Lymphocytes
Coloring Agents
Macrophages
Lymphocytes
Staining and Labeling
T-Lymphocytes
Light
Population

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Thyroid multifocal granulomatous folliculitis (palpation thyroiditis) : An immunocytochemical study. / Harach, H. Ruben; Jasani, Bharat.

In: Endocrine Pathology, Vol. 4, No. 2, 06.1993, p. 105-109.

Research output: Contribution to journalArticle

Harach, H. Ruben ; Jasani, Bharat. / Thyroid multifocal granulomatous folliculitis (palpation thyroiditis) : An immunocytochemical study. In: Endocrine Pathology. 1993 ; Vol. 4, No. 2. pp. 105-109.
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