Tairon kak spinovaia lovushka dlia superoksidnykh radikalov, obrazuemykh dykhatel'noǐ tsep'iu sybmitokhondrial'nykh chastits.

Translated title of the contribution: Tiron as a spin-trap for superoxide radicals produced by the respiratory chain of submitochondrial particles

I. V. Grigolava, M. I. Ksenzenko, A. A. Konstantinob, A. N. Tikhonov, T. M. Kerimov

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)

Abstract

Tiron can be used as a spin-trap for O2 radicals generated by the respiratory chain of submitochondrial particles (SMP). Using this sensitive method, it was shown that the O2 (radical) production by the succinate-oxidizing SMP can be reduced by antimycin or 4-nonyl-2-hydroxyquinoline-N-oxide, the effects of both antibiotics being abolished and prevented by cyanide. It is suggested tht the O2 radicals are produced due to autooxidation of ubisemiquinone which is formed as an intermediate upon one-electron oxidation of CoQH2 by cytochrome c1. The effects of antimycin, 2-nonyl-4-hydroxyquinoline-N-oxide and cyanide on the O2 (radical) generation correlate with the effects of these inhibitors on a steady-state concentration of ubisemiquinone predicted by the Mitchell's Q-cycle hypothesis.

Translated title of the contributionTiron as a spin-trap for superoxide radicals produced by the respiratory chain of submitochondrial particles
Original languageRussian
Pages (from-to)75-82
Number of pages8
JournalBiokhimiya
Volume45
Issue number1
Publication statusPublished - Jan 1 1980
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry(all)

Fingerprint Dive into the research topics of 'Tiron as a spin-trap for superoxide radicals produced by the respiratory chain of submitochondrial particles'. Together they form a unique fingerprint.

Cite this