Towards a comprehensive catalog of zebrafish behavior 1.0 and beyond

Allan V. Kalueff, Michael Gebhardt, Adam Michael Stewart, Jonathan M. Cachat, Mallorie Brimmer, Jonathan S. Chawla, Cassandra Craddock, Evan J. Kyzar, Andrew Roth, Samuel Landsman, Siddharth Gaikwad, Kyle Robinson, Erik Baatrup, Keith Tierney, Angela Shamchuk, William Norton, Noam Miller, Teresa Nicolson, Oliver Braubach, Charles P. GilmanJulian Pittman, Denis B. Rosemberg, Robert Gerlai, David Echevarria, Elisabeth Lamb, Stephan C F Neuhauss, Wei Weng, Laure Bally-Cuif, Henning Schneider

Research output: Contribution to journalReview article

392 Citations (Scopus)

Abstract

Zebrafish (Danio rerio) are rapidly gaining popularity in translational neuroscience and behavioral research. Physiological similarity to mammals, ease of genetic manipulations, sensitivity to pharmacological and genetic factors, robust behavior, low cost, and potential for high-throughput screening contribute to the growing utility of zebrafish models in this field. Understanding zebrafish behavioral phenotypes provides important insights into neural pathways, physiological biomarkers, and genetic underpinnings of normal and pathological brain function. Novel zebrafish paradigms continue to appear with an encouraging pace, thus necessitating a consistent terminology and improved understanding of the behavioral repertoire. What can zebrafish 'do', and how does their altered brain function translate into behavioral actions? To help address these questions, we have developed a detailed catalog of zebrafish behaviors (Zebrafish Behavior Catalog, ZBC) that covers both larval and adult models. Representing a beginning of creating a more comprehensive ethogram of zebrafish behavior, this effort will improve interpretation of published findings, foster cross-species behavioral modeling, and encourage new groups to apply zebrafish neurobehavioral paradigms in their research. In addition, this glossary creates a framework for developing a zebrafish neurobehavioral ontology, ultimately to become part of a unified animal neurobehavioral ontology, which collectively will contribute to better integration of biological data within and across species.

Original languageEnglish
Pages (from-to)70-86
Number of pages17
JournalZebrafish
Volume10
Issue number1
DOIs
Publication statusPublished - Mar 1 2013
Externally publishedYes

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Developmental Biology

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  • Cite this

    Kalueff, A. V., Gebhardt, M., Stewart, A. M., Cachat, J. M., Brimmer, M., Chawla, J. S., Craddock, C., Kyzar, E. J., Roth, A., Landsman, S., Gaikwad, S., Robinson, K., Baatrup, E., Tierney, K., Shamchuk, A., Norton, W., Miller, N., Nicolson, T., Braubach, O., ... Schneider, H. (2013). Towards a comprehensive catalog of zebrafish behavior 1.0 and beyond. Zebrafish, 10(1), 70-86. https://doi.org/10.1089/zeb.2012.0861