Abstract
In recent years, paramagnetic nanoparticles (NPs) have been widely used for magnetic resonance imaging (MRI). This paper reports the fabrication and toxicity evaluation of polyethylene glycol (PEG)-functionalized holmium oxide (Ho2O3) NPs for potential T2-weighted MRI applications. Various characterization techniques were used to examine the morphology, structure and chemical properties of the prepared PEG–Ho2O3 NPs. MRI relaxivity measurements revealed that PEG–Ho2O3 NPs could generate a strong negative contrast in T2-weighted MRI. The pilot cytotoxicity experiments showed that the prepared PEG–Ho2O3 NPs are biocompatible at concentrations less than 16 µg/mL. Overall, the prepared PEG–Ho2O3 NPs have potential applications for T2-weighted MRI imaging.
| Original language | English |
|---|---|
| Article number | 216 |
| Journal | Nanomaterials |
| Volume | 7 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - Aug 7 2017 |
| Externally published | Yes |
Fingerprint
Keywords
- Holmium oxide
- Paramagnetic nanoparticles
- T-weighted magnetic resonance imaging
- Toxicity
ASJC Scopus subject areas
- Materials Science(all)
- Chemical Engineering(all)
Cite this
Toxicity and t2-weighted magnetic resonance imaging potentials of holmium oxide nanoparticles. / Atabaev, Timur Sh; Shin, Yong Cheol; Song, Su Jin; Han, Dong Wook; Hong, Nguyen Hoa.
In: Nanomaterials, Vol. 7, No. 8, 216, 07.08.2017.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Toxicity and t2-weighted magnetic resonance imaging potentials of holmium oxide nanoparticles
AU - Atabaev, Timur Sh
AU - Shin, Yong Cheol
AU - Song, Su Jin
AU - Han, Dong Wook
AU - Hong, Nguyen Hoa
PY - 2017/8/7
Y1 - 2017/8/7
N2 - In recent years, paramagnetic nanoparticles (NPs) have been widely used for magnetic resonance imaging (MRI). This paper reports the fabrication and toxicity evaluation of polyethylene glycol (PEG)-functionalized holmium oxide (Ho2O3) NPs for potential T2-weighted MRI applications. Various characterization techniques were used to examine the morphology, structure and chemical properties of the prepared PEG–Ho2O3 NPs. MRI relaxivity measurements revealed that PEG–Ho2O3 NPs could generate a strong negative contrast in T2-weighted MRI. The pilot cytotoxicity experiments showed that the prepared PEG–Ho2O3 NPs are biocompatible at concentrations less than 16 µg/mL. Overall, the prepared PEG–Ho2O3 NPs have potential applications for T2-weighted MRI imaging.
AB - In recent years, paramagnetic nanoparticles (NPs) have been widely used for magnetic resonance imaging (MRI). This paper reports the fabrication and toxicity evaluation of polyethylene glycol (PEG)-functionalized holmium oxide (Ho2O3) NPs for potential T2-weighted MRI applications. Various characterization techniques were used to examine the morphology, structure and chemical properties of the prepared PEG–Ho2O3 NPs. MRI relaxivity measurements revealed that PEG–Ho2O3 NPs could generate a strong negative contrast in T2-weighted MRI. The pilot cytotoxicity experiments showed that the prepared PEG–Ho2O3 NPs are biocompatible at concentrations less than 16 µg/mL. Overall, the prepared PEG–Ho2O3 NPs have potential applications for T2-weighted MRI imaging.
KW - Holmium oxide
KW - Paramagnetic nanoparticles
KW - T-weighted magnetic resonance imaging
KW - Toxicity
UR - http://www.scopus.com/inward/record.url?scp=85027345156&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85027345156&partnerID=8YFLogxK
U2 - 10.3390/nano7080216
DO - 10.3390/nano7080216
M3 - Article
VL - 7
JO - Nanomaterials
JF - Nanomaterials
SN - 2079-4991
IS - 8
M1 - 216
ER -