Toxicity and t2-weighted magnetic resonance imaging potentials of holmium oxide nanoparticles

Timur Sh Atabaev; Yong Cheol Shin; Su Jin Song; Dong Wook Han; Nguyen Hoa Hong

doi:10.3390/nano7080216

Toxicity and t₂-weighted magnetic resonance imaging potentials of holmium oxide nanoparticles

Timur Sh Atabaev, Yong Cheol Shin, Su Jin Song, Dong Wook Han, Nguyen Hoa Hong

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

In recent years, paramagnetic nanoparticles (NPs) have been widely used for magnetic resonance imaging (MRI). This paper reports the fabrication and toxicity evaluation of polyethylene glycol (PEG)-functionalized holmium oxide (Ho₂O₃) NPs for potential T₂-weighted MRI applications. Various characterization techniques were used to examine the morphology, structure and chemical properties of the prepared PEG–Ho₂O₃ NPs. MRI relaxivity measurements revealed that PEG–Ho₂O₃ NPs could generate a strong negative contrast in T₂-weighted MRI. The pilot cytotoxicity experiments showed that the prepared PEG–Ho₂O₃ NPs are biocompatible at concentrations less than 16 µg/mL. Overall, the prepared PEG–Ho₂O₃ NPs have potential applications for T₂-weighted MRI imaging.

Original language	English
Article number	216
Journal	Nanomaterials
Volume	7
Issue number	8
DOIs	https://doi.org/10.3390/nano7080216
Publication status	Published - Aug 7 2017
Externally published	Yes

Keywords

Holmium oxide
Paramagnetic nanoparticles
T-weighted magnetic resonance imaging
Toxicity

ASJC Scopus subject areas

Materials Science(all)
Chemical Engineering(all)

Access to Document

10.3390/nano7080216

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title = "Toxicity and t2-weighted magnetic resonance imaging potentials of holmium oxide nanoparticles",

abstract = "In recent years, paramagnetic nanoparticles (NPs) have been widely used for magnetic resonance imaging (MRI). This paper reports the fabrication and toxicity evaluation of polyethylene glycol (PEG)-functionalized holmium oxide (Ho2O3) NPs for potential T2-weighted MRI applications. Various characterization techniques were used to examine the morphology, structure and chemical properties of the prepared PEG–Ho2O3 NPs. MRI relaxivity measurements revealed that PEG–Ho2O3 NPs could generate a strong negative contrast in T2-weighted MRI. The pilot cytotoxicity experiments showed that the prepared PEG–Ho2O3 NPs are biocompatible at concentrations less than 16 µg/mL. Overall, the prepared PEG–Ho2O3 NPs have potential applications for T2-weighted MRI imaging.",

keywords = "Holmium oxide, Paramagnetic nanoparticles, T-weighted magnetic resonance imaging, Toxicity",

author = "Atabaev, {Timur Sh} and Shin, {Yong Cheol} and Song, {Su Jin} and Han, {Dong Wook} and Hong, {Nguyen Hoa}",

note = "Funding Information: This work was supported by the BK21 PLUS program at the Department of Physics and Astronomy, Seoul National University. This research was financially supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (No. 2016R1D1A1B03931076). Part of this study has been performed using facilities at IBS Center for Correlated Electron Systems, Seoul National University.",

year = "2017",

month = aug,

day = "7",

doi = "10.3390/nano7080216",

language = "English",

volume = "7",

journal = "Nanomaterials",

issn = "2079-4991",

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T1 - Toxicity and t2-weighted magnetic resonance imaging potentials of holmium oxide nanoparticles

AU - Atabaev, Timur Sh

AU - Shin, Yong Cheol

AU - Song, Su Jin

AU - Han, Dong Wook

AU - Hong, Nguyen Hoa

N1 - Funding Information: This work was supported by the BK21 PLUS program at the Department of Physics and Astronomy, Seoul National University. This research was financially supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (No. 2016R1D1A1B03931076). Part of this study has been performed using facilities at IBS Center for Correlated Electron Systems, Seoul National University.

PY - 2017/8/7

Y1 - 2017/8/7

N2 - In recent years, paramagnetic nanoparticles (NPs) have been widely used for magnetic resonance imaging (MRI). This paper reports the fabrication and toxicity evaluation of polyethylene glycol (PEG)-functionalized holmium oxide (Ho2O3) NPs for potential T2-weighted MRI applications. Various characterization techniques were used to examine the morphology, structure and chemical properties of the prepared PEG–Ho2O3 NPs. MRI relaxivity measurements revealed that PEG–Ho2O3 NPs could generate a strong negative contrast in T2-weighted MRI. The pilot cytotoxicity experiments showed that the prepared PEG–Ho2O3 NPs are biocompatible at concentrations less than 16 µg/mL. Overall, the prepared PEG–Ho2O3 NPs have potential applications for T2-weighted MRI imaging.

AB - In recent years, paramagnetic nanoparticles (NPs) have been widely used for magnetic resonance imaging (MRI). This paper reports the fabrication and toxicity evaluation of polyethylene glycol (PEG)-functionalized holmium oxide (Ho2O3) NPs for potential T2-weighted MRI applications. Various characterization techniques were used to examine the morphology, structure and chemical properties of the prepared PEG–Ho2O3 NPs. MRI relaxivity measurements revealed that PEG–Ho2O3 NPs could generate a strong negative contrast in T2-weighted MRI. The pilot cytotoxicity experiments showed that the prepared PEG–Ho2O3 NPs are biocompatible at concentrations less than 16 µg/mL. Overall, the prepared PEG–Ho2O3 NPs have potential applications for T2-weighted MRI imaging.

KW - Holmium oxide

KW - Paramagnetic nanoparticles

KW - T-weighted magnetic resonance imaging

KW - Toxicity

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