Toxicity and t2-weighted magnetic resonance imaging potentials of holmium oxide nanoparticles

Timur Sh Atabaev, Yong Cheol Shin, Su Jin Song, Dong Wook Han, Nguyen Hoa Hong

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

In recent years, paramagnetic nanoparticles (NPs) have been widely used for magnetic resonance imaging (MRI). This paper reports the fabrication and toxicity evaluation of polyethylene glycol (PEG)-functionalized holmium oxide (Ho2O3) NPs for potential T2-weighted MRI applications. Various characterization techniques were used to examine the morphology, structure and chemical properties of the prepared PEG–Ho2O3 NPs. MRI relaxivity measurements revealed that PEG–Ho2O3 NPs could generate a strong negative contrast in T2-weighted MRI. The pilot cytotoxicity experiments showed that the prepared PEG–Ho2O3 NPs are biocompatible at concentrations less than 16 µg/mL. Overall, the prepared PEG–Ho2O3 NPs have potential applications for T2-weighted MRI imaging.

Original languageEnglish
Article number216
JournalNanomaterials
Volume7
Issue number8
DOIs
Publication statusPublished - Aug 7 2017
Externally publishedYes

Fingerprint

Holmium
Magnetic resonance
Oxides
Toxicity
Nanoparticles
Imaging techniques
Cytotoxicity
Chemical properties
Polyethylene glycols
Fabrication

Keywords

  • Holmium oxide
  • Paramagnetic nanoparticles
  • T-weighted magnetic resonance imaging
  • Toxicity

ASJC Scopus subject areas

  • Materials Science(all)
  • Chemical Engineering(all)

Cite this

Toxicity and t2-weighted magnetic resonance imaging potentials of holmium oxide nanoparticles. / Atabaev, Timur Sh; Shin, Yong Cheol; Song, Su Jin; Han, Dong Wook; Hong, Nguyen Hoa.

In: Nanomaterials, Vol. 7, No. 8, 216, 07.08.2017.

Research output: Contribution to journalArticle

Atabaev, Timur Sh ; Shin, Yong Cheol ; Song, Su Jin ; Han, Dong Wook ; Hong, Nguyen Hoa. / Toxicity and t2-weighted magnetic resonance imaging potentials of holmium oxide nanoparticles. In: Nanomaterials. 2017 ; Vol. 7, No. 8.
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