Toxicity and t2-weighted magnetic resonance imaging potentials of holmium oxide nanoparticles

Timur Sh Atabaev, Yong Cheol Shin, Su Jin Song, Dong Wook Han, Nguyen Hoa Hong

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

In recent years, paramagnetic nanoparticles (NPs) have been widely used for magnetic resonance imaging (MRI). This paper reports the fabrication and toxicity evaluation of polyethylene glycol (PEG)-functionalized holmium oxide (Ho2O3) NPs for potential T2-weighted MRI applications. Various characterization techniques were used to examine the morphology, structure and chemical properties of the prepared PEG–Ho2O3 NPs. MRI relaxivity measurements revealed that PEG–Ho2O3 NPs could generate a strong negative contrast in T2-weighted MRI. The pilot cytotoxicity experiments showed that the prepared PEG–Ho2O3 NPs are biocompatible at concentrations less than 16 µg/mL. Overall, the prepared PEG–Ho2O3 NPs have potential applications for T2-weighted MRI imaging.

Original languageEnglish
Article number216
JournalNanomaterials
Volume7
Issue number8
DOIs
Publication statusPublished - Aug 7 2017
Externally publishedYes

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Keywords

  • Holmium oxide
  • Paramagnetic nanoparticles
  • T-weighted magnetic resonance imaging
  • Toxicity

ASJC Scopus subject areas

  • Materials Science(all)
  • Chemical Engineering(all)

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