Traditional risk factors of acute coronary syndrome in four different male populations - total cholesterol value does not seem to be relevant risk factor

J A Hubacek, V Stanek, M Gebauerova, V Adamkova, V Lesauskaite, D Zaliaduonyte-Peksiene, A Tamosiunas, A Supiyev, A Kossumov, A Zhumadilova, J Pitha

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Abstract

Cardiovascular diseases are the most common cause of mortality and morbidity in most populations. As the traditional modifiable risk factors (smoking, hypertension, dyslipidemia, diabetes mellitus, and obesity) were defined decades ago, we decided to analyze recent data in patients who survived acute coronary syndrome (ACS). The Czech part of the study included data from 999 males, and compared them with the post-MONICA study (1,259 males, representing general population). The Lithuanian study included 479 male patients and 456 age-matched controls. The Kazakhstan part included 232 patients and 413 controls. In two countries, the most robust ACS risk factor was smoking (OR 3.85 in the Czech study and 5.76 in the Lithuanian study), followed by diabetes (OR 2.26 and 2.07) and hypertension (moderate risk elevation with OR 1.43 and 1.49). These factors did not influence the ACS risk in Kazakhstan. BMI had no significant effect on ACS and plasma cholesterol was surprisingly significantly lower (P<0.001) in patients than in controls in all countries (4.80+/-1.11 vs. 5.76+/-1.06 mmol/l in Czechs; 5.32+/-1.32 vs. 5.71+/-1.08 mmol/l in Lithuanians; 4.88+/-1.05 vs. 5.38+/-1.13 mmol/l in Kazakhs/Russians). Results from our study indicate substantial heterogeneity regarding major CVD risk factors in different populations with the exception of plasma total cholesterol which was inversely associated with ACS risk in all involved groups. These data reflect ethnical and geographical differences as well as changing pattern of cardiovascular risk profiles.

Original languageEnglish
Pages (from-to)S121-S128
JournalPhysiological Research
Volume66
Issue numberSupplementum 1
Publication statusPublished - Apr 5 2017

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Acute Coronary Syndrome
Cholesterol
Kazakhstan
Population
Smoking
Hypertension
Dyslipidemias
Diabetes Mellitus
Cardiovascular Diseases
Obesity
Morbidity
Mortality

Keywords

  • Acute Coronary Syndrome
  • Aged
  • Cholesterol
  • Czech Republic
  • Humans
  • Kazakhstan
  • Lithuania
  • Male
  • Middle Aged
  • Risk Factors
  • Journal Article

Cite this

Hubacek, J. A., Stanek, V., Gebauerova, M., Adamkova, V., Lesauskaite, V., Zaliaduonyte-Peksiene, D., ... Pitha, J. (2017). Traditional risk factors of acute coronary syndrome in four different male populations - total cholesterol value does not seem to be relevant risk factor. Physiological Research, 66(Supplementum 1), S121-S128.

Traditional risk factors of acute coronary syndrome in four different male populations - total cholesterol value does not seem to be relevant risk factor. / Hubacek, J A; Stanek, V; Gebauerova, M; Adamkova, V; Lesauskaite, V; Zaliaduonyte-Peksiene, D; Tamosiunas, A; Supiyev, A; Kossumov, A; Zhumadilova, A; Pitha, J.

In: Physiological Research, Vol. 66, No. Supplementum 1, 05.04.2017, p. S121-S128.

Research output: Contribution to journalArticle

Hubacek, JA, Stanek, V, Gebauerova, M, Adamkova, V, Lesauskaite, V, Zaliaduonyte-Peksiene, D, Tamosiunas, A, Supiyev, A, Kossumov, A, Zhumadilova, A & Pitha, J 2017, 'Traditional risk factors of acute coronary syndrome in four different male populations - total cholesterol value does not seem to be relevant risk factor', Physiological Research, vol. 66, no. Supplementum 1, pp. S121-S128.
Hubacek JA, Stanek V, Gebauerova M, Adamkova V, Lesauskaite V, Zaliaduonyte-Peksiene D et al. Traditional risk factors of acute coronary syndrome in four different male populations - total cholesterol value does not seem to be relevant risk factor. Physiological Research. 2017 Apr 5;66(Supplementum 1):S121-S128.
Hubacek, J A ; Stanek, V ; Gebauerova, M ; Adamkova, V ; Lesauskaite, V ; Zaliaduonyte-Peksiene, D ; Tamosiunas, A ; Supiyev, A ; Kossumov, A ; Zhumadilova, A ; Pitha, J. / Traditional risk factors of acute coronary syndrome in four different male populations - total cholesterol value does not seem to be relevant risk factor. In: Physiological Research. 2017 ; Vol. 66, No. Supplementum 1. pp. S121-S128.
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