Treatment of PPROM with anhydramnion in humans

First experience with different amniotic fluid substitutes for continuous amnioinfusion through a subcutaneously implanted port system

Michael Tchirikov, Gauri Bapayeva, Zhaxybay Sh Zhumadilov, Yasmina Dridi, Ralf Harnisch, Angelika Herrmann

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objective: This study aims to treat patients with preterm premature rupture of the membranes (PPROM) and anhydramnion using continuous amnioinfusion through a subcutaneously implanted port system. Methods: An amniotic fluid replacement port system was implanted in seven patients with PPROM and anhydramnion starting at the 20th week of gestation (range, 14-26 weeks) for long-term amnioinfusion. Saline solutions (2 L/day; Jonosteril®, Sterofundin®, isotonic NaCl 0.9% solution, lactated Ringer's solution) and a hypotonic aqueous composition with reduced chloride content similar to the electrolyte concentration of human amniotic fluid were used for the continuous amnioinfusion. Results: The mean duration of the PPROM delivery interval continued for 49 days (range, 9-69 days), with 3 weeks of amnioinfusion via the port system (range, 4-49). The newborns showed no signs of lung hypoplasia. Conclusion: Long-term lavage of the amniotic cavity via a subcutaneously implanted port system in patients with PPROM and anhydramnion may help prolong the pregnancy and avoid fetal lung hypoplasia. A hypotonic aqueous composition with reduced chloride content similar to human amniotic fluid can be safely used for amnioinfusion. Prospective randomized studies are ongoing.

Original languageEnglish
Pages (from-to)657-663
Number of pages7
JournalJournal of Perinatal Medicine
Volume41
Issue number6
DOIs
Publication statusPublished - 2013

Fingerprint

Amniotic Fluid
Chlorides
Pregnancy
Lung
Therapeutic Irrigation
Therapeutics
Sodium Chloride
Electrolytes
Newborn Infant
Prospective Studies
Preterm Premature Rupture of the Membranes

Keywords

  • Amnioinfusion
  • Amniotic fluid substitute
  • Anhydramnion
  • Port system
  • PPROM

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Pediatrics, Perinatology, and Child Health

Cite this

Treatment of PPROM with anhydramnion in humans : First experience with different amniotic fluid substitutes for continuous amnioinfusion through a subcutaneously implanted port system. / Tchirikov, Michael; Bapayeva, Gauri; Zhumadilov, Zhaxybay Sh; Dridi, Yasmina; Harnisch, Ralf; Herrmann, Angelika.

In: Journal of Perinatal Medicine, Vol. 41, No. 6, 2013, p. 657-663.

Research output: Contribution to journalArticle

@article{125c5f0c21c34867a5c5ae6579ab61e3,
title = "Treatment of PPROM with anhydramnion in humans: First experience with different amniotic fluid substitutes for continuous amnioinfusion through a subcutaneously implanted port system",
abstract = "Objective: This study aims to treat patients with preterm premature rupture of the membranes (PPROM) and anhydramnion using continuous amnioinfusion through a subcutaneously implanted port system. Methods: An amniotic fluid replacement port system was implanted in seven patients with PPROM and anhydramnion starting at the 20th week of gestation (range, 14-26 weeks) for long-term amnioinfusion. Saline solutions (2 L/day; Jonosteril{\circledR}, Sterofundin{\circledR}, isotonic NaCl 0.9{\%} solution, lactated Ringer's solution) and a hypotonic aqueous composition with reduced chloride content similar to the electrolyte concentration of human amniotic fluid were used for the continuous amnioinfusion. Results: The mean duration of the PPROM delivery interval continued for 49 days (range, 9-69 days), with 3 weeks of amnioinfusion via the port system (range, 4-49). The newborns showed no signs of lung hypoplasia. Conclusion: Long-term lavage of the amniotic cavity via a subcutaneously implanted port system in patients with PPROM and anhydramnion may help prolong the pregnancy and avoid fetal lung hypoplasia. A hypotonic aqueous composition with reduced chloride content similar to human amniotic fluid can be safely used for amnioinfusion. Prospective randomized studies are ongoing.",
keywords = "Amnioinfusion, Amniotic fluid substitute, Anhydramnion, Port system, PPROM",
author = "Michael Tchirikov and Gauri Bapayeva and Zhumadilov, {Zhaxybay Sh} and Yasmina Dridi and Ralf Harnisch and Angelika Herrmann",
year = "2013",
doi = "10.1515/jpm-2012-0296",
language = "English",
volume = "41",
pages = "657--663",
journal = "Journal of Perinatal Medicine",
issn = "0300-5577",
publisher = "Walter de Gruyter GmbH & Co. KG",
number = "6",

}

TY - JOUR

T1 - Treatment of PPROM with anhydramnion in humans

T2 - First experience with different amniotic fluid substitutes for continuous amnioinfusion through a subcutaneously implanted port system

AU - Tchirikov, Michael

AU - Bapayeva, Gauri

AU - Zhumadilov, Zhaxybay Sh

AU - Dridi, Yasmina

AU - Harnisch, Ralf

AU - Herrmann, Angelika

PY - 2013

Y1 - 2013

N2 - Objective: This study aims to treat patients with preterm premature rupture of the membranes (PPROM) and anhydramnion using continuous amnioinfusion through a subcutaneously implanted port system. Methods: An amniotic fluid replacement port system was implanted in seven patients with PPROM and anhydramnion starting at the 20th week of gestation (range, 14-26 weeks) for long-term amnioinfusion. Saline solutions (2 L/day; Jonosteril®, Sterofundin®, isotonic NaCl 0.9% solution, lactated Ringer's solution) and a hypotonic aqueous composition with reduced chloride content similar to the electrolyte concentration of human amniotic fluid were used for the continuous amnioinfusion. Results: The mean duration of the PPROM delivery interval continued for 49 days (range, 9-69 days), with 3 weeks of amnioinfusion via the port system (range, 4-49). The newborns showed no signs of lung hypoplasia. Conclusion: Long-term lavage of the amniotic cavity via a subcutaneously implanted port system in patients with PPROM and anhydramnion may help prolong the pregnancy and avoid fetal lung hypoplasia. A hypotonic aqueous composition with reduced chloride content similar to human amniotic fluid can be safely used for amnioinfusion. Prospective randomized studies are ongoing.

AB - Objective: This study aims to treat patients with preterm premature rupture of the membranes (PPROM) and anhydramnion using continuous amnioinfusion through a subcutaneously implanted port system. Methods: An amniotic fluid replacement port system was implanted in seven patients with PPROM and anhydramnion starting at the 20th week of gestation (range, 14-26 weeks) for long-term amnioinfusion. Saline solutions (2 L/day; Jonosteril®, Sterofundin®, isotonic NaCl 0.9% solution, lactated Ringer's solution) and a hypotonic aqueous composition with reduced chloride content similar to the electrolyte concentration of human amniotic fluid were used for the continuous amnioinfusion. Results: The mean duration of the PPROM delivery interval continued for 49 days (range, 9-69 days), with 3 weeks of amnioinfusion via the port system (range, 4-49). The newborns showed no signs of lung hypoplasia. Conclusion: Long-term lavage of the amniotic cavity via a subcutaneously implanted port system in patients with PPROM and anhydramnion may help prolong the pregnancy and avoid fetal lung hypoplasia. A hypotonic aqueous composition with reduced chloride content similar to human amniotic fluid can be safely used for amnioinfusion. Prospective randomized studies are ongoing.

KW - Amnioinfusion

KW - Amniotic fluid substitute

KW - Anhydramnion

KW - Port system

KW - PPROM

UR - http://www.scopus.com/inward/record.url?scp=84888607320&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84888607320&partnerID=8YFLogxK

U2 - 10.1515/jpm-2012-0296

DO - 10.1515/jpm-2012-0296

M3 - Article

VL - 41

SP - 657

EP - 663

JO - Journal of Perinatal Medicine

JF - Journal of Perinatal Medicine

SN - 0300-5577

IS - 6

ER -