Treatment of PPROM with anhydramnion in humans: First experience with different amniotic fluid substitutes for continuous amnioinfusion through a subcutaneously implanted port system

Michael Tchirikov, Gauri Bapayeva, Zhaxybay Sh Zhumadilov, Yasmina Dridi, Ralf Harnisch, Angelika Herrmann

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Objective: This study aims to treat patients with preterm premature rupture of the membranes (PPROM) and anhydramnion using continuous amnioinfusion through a subcutaneously implanted port system. Methods: An amniotic fluid replacement port system was implanted in seven patients with PPROM and anhydramnion starting at the 20th week of gestation (range, 14-26 weeks) for long-term amnioinfusion. Saline solutions (2 L/day; Jonosteril®, Sterofundin®, isotonic NaCl 0.9% solution, lactated Ringer's solution) and a hypotonic aqueous composition with reduced chloride content similar to the electrolyte concentration of human amniotic fluid were used for the continuous amnioinfusion. Results: The mean duration of the PPROM delivery interval continued for 49 days (range, 9-69 days), with 3 weeks of amnioinfusion via the port system (range, 4-49). The newborns showed no signs of lung hypoplasia. Conclusion: Long-term lavage of the amniotic cavity via a subcutaneously implanted port system in patients with PPROM and anhydramnion may help prolong the pregnancy and avoid fetal lung hypoplasia. A hypotonic aqueous composition with reduced chloride content similar to human amniotic fluid can be safely used for amnioinfusion. Prospective randomized studies are ongoing.

Original languageEnglish
Pages (from-to)657-663
Number of pages7
JournalJournal of Perinatal Medicine
Volume41
Issue number6
DOIs
Publication statusPublished - 2013

Keywords

  • Amnioinfusion
  • Amniotic fluid substitute
  • Anhydramnion
  • PPROM
  • Port system

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynaecology

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