Tuberculosis-immune reconstitution inflammatory syndrome

Massimiliano Lanzafame, Sandro Vento

Research output: Contribution to journalReview article

17 Citations (Scopus)

Abstract

Tuberculosis-immune reconstitution inflammatory syndrome is an excessive immune response against Mycobacterium tuberculosis that may occur in either HIV-infected or uninfected patients, during or after completion of anti-TB therapy. In HIV-infected patients it occurs after initiation of antiretroviral therapy independently from an effective suppression of HIV viremia. There are two forms of IRIS: paradoxical or unmasking. Paradoxical IRIS is characterized by recurrent, new, or worsening symptoms of a treated case. Unmasking IRIS is an antiretroviral-associated inflammatory manifestation of a subclinical infection with a hastened presentation. The pathogenesis is incompletely understood and the epidemiology partially described. No specific tests can establish or rule out the diagnosis. Treatment is based on the use of anti-tuberculosis drugs sometime with adjunctive corticosteroids. Mortality is generally low.

Original languageEnglish
Pages (from-to)6-9
Number of pages4
JournalJournal of Clinical Tuberculosis and Other Mycobacterial Diseases
Volume3
DOIs
Publication statusPublished - May 1 2016

Keywords

  • Antiretrovirals
  • HIV
  • Immune reconstitution
  • IRIS
  • Tuberculosis

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases
  • Microbiology (medical)

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