Abstract
Tuberculosis-immune reconstitution inflammatory syndrome is an excessive immune response against Mycobacterium tuberculosis that may occur in either HIV-infected or uninfected patients, during or after completion of anti-TB therapy. In HIV-infected patients it occurs after initiation of antiretroviral therapy independently from an effective suppression of HIV viremia. There are two forms of IRIS: paradoxical or unmasking. Paradoxical IRIS is characterized by recurrent, new, or worsening symptoms of a treated case. Unmasking IRIS is an antiretroviral-associated inflammatory manifestation of a subclinical infection with a hastened presentation. The pathogenesis is incompletely understood and the epidemiology partially described. No specific tests can establish or rule out the diagnosis. Treatment is based on the use of anti-tuberculosis drugs sometime with adjunctive corticosteroids. Mortality is generally low.
| Original language | English |
|---|---|
| Pages (from-to) | 6-9 |
| Number of pages | 4 |
| Journal | Journal of Clinical Tuberculosis and Other Mycobacterial Diseases |
| Volume | 3 |
| DOIs | |
| Publication status | Published - May 1 2016 |
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Keywords
- Antiretrovirals
- HIV
- Immune reconstitution
- IRIS
- Tuberculosis
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine
- Infectious Diseases
- Microbiology (medical)
Cite this
Tuberculosis-immune reconstitution inflammatory syndrome. / Lanzafame, Massimiliano; Vento, Sandro.
In: Journal of Clinical Tuberculosis and Other Mycobacterial Diseases, Vol. 3, 01.05.2016, p. 6-9.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Tuberculosis-immune reconstitution inflammatory syndrome
AU - Lanzafame, Massimiliano
AU - Vento, Sandro
PY - 2016/5/1
Y1 - 2016/5/1
N2 - Tuberculosis-immune reconstitution inflammatory syndrome is an excessive immune response against Mycobacterium tuberculosis that may occur in either HIV-infected or uninfected patients, during or after completion of anti-TB therapy. In HIV-infected patients it occurs after initiation of antiretroviral therapy independently from an effective suppression of HIV viremia. There are two forms of IRIS: paradoxical or unmasking. Paradoxical IRIS is characterized by recurrent, new, or worsening symptoms of a treated case. Unmasking IRIS is an antiretroviral-associated inflammatory manifestation of a subclinical infection with a hastened presentation. The pathogenesis is incompletely understood and the epidemiology partially described. No specific tests can establish or rule out the diagnosis. Treatment is based on the use of anti-tuberculosis drugs sometime with adjunctive corticosteroids. Mortality is generally low.
AB - Tuberculosis-immune reconstitution inflammatory syndrome is an excessive immune response against Mycobacterium tuberculosis that may occur in either HIV-infected or uninfected patients, during or after completion of anti-TB therapy. In HIV-infected patients it occurs after initiation of antiretroviral therapy independently from an effective suppression of HIV viremia. There are two forms of IRIS: paradoxical or unmasking. Paradoxical IRIS is characterized by recurrent, new, or worsening symptoms of a treated case. Unmasking IRIS is an antiretroviral-associated inflammatory manifestation of a subclinical infection with a hastened presentation. The pathogenesis is incompletely understood and the epidemiology partially described. No specific tests can establish or rule out the diagnosis. Treatment is based on the use of anti-tuberculosis drugs sometime with adjunctive corticosteroids. Mortality is generally low.
KW - Antiretrovirals
KW - HIV
KW - Immune reconstitution
KW - IRIS
KW - Tuberculosis
UR - http://www.scopus.com/inward/record.url?scp=84961595319&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84961595319&partnerID=8YFLogxK
U2 - 10.1016/j.jctube.2016.03.002
DO - 10.1016/j.jctube.2016.03.002
M3 - Review article
VL - 3
SP - 6
EP - 9
JO - Journal of Clinical Tuberculosis and Other Mycobacterial Diseases
JF - Journal of Clinical Tuberculosis and Other Mycobacterial Diseases
SN - 2405-5794
ER -