Abstract
Tuberculosis-immune reconstitution inflammatory syndrome is an excessive immune response against Mycobacterium tuberculosis that may occur in either HIV-infected or uninfected patients, during or after completion of anti-TB therapy. In HIV-infected patients it occurs after initiation of antiretroviral therapy independently from an effective suppression of HIV viremia. There are two forms of IRIS: paradoxical or unmasking. Paradoxical IRIS is characterized by recurrent, new, or worsening symptoms of a treated case. Unmasking IRIS is an antiretroviral-associated inflammatory manifestation of a subclinical infection with a hastened presentation. The pathogenesis is incompletely understood and the epidemiology partially described. No specific tests can establish or rule out the diagnosis. Treatment is based on the use of anti-tuberculosis drugs sometime with adjunctive corticosteroids. Mortality is generally low.
Original language | English |
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Pages (from-to) | 6-9 |
Number of pages | 4 |
Journal | Journal of Clinical Tuberculosis and Other Mycobacterial Diseases |
Volume | 3 |
DOIs | |
Publication status | Published - May 1 2016 |
Keywords
- Antiretrovirals
- HIV
- IRIS
- Immune reconstitution
- Tuberculosis
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine
- Microbiology (medical)
- Infectious Diseases