TY - JOUR
T1 - Tuberculosis in Kazakhstan
T2 - Analysis of risk determinants in national surveillance data
AU - Terlikbayeva, Assel
AU - Hermosilla, Sabrina
AU - Galea, Sandro
AU - Schluger, Neil
AU - Yegeubayeva, Saltanat
AU - Abildayev, Tleukhan
AU - Muminov, Talgat
AU - Akiyanova, Farida
AU - Bartkowiak, Laura
AU - Zhumadilov, Zhaksybay
AU - Sharman, Almaz
AU - El-Bassel, Nabila
PY - 2012/10/18
Y1 - 2012/10/18
N2 - Background: Development of tuberculosis (TB) is determined by various risk factors and the interactions of temporal and spatial distributions. The aim of this study was to identify the most salient risk factors for TB disease as well as multidrug resistant TB (MDR-TB) at the oblast (provincial) level in Kazakhstan.Methods: Correlational and descriptive analyses were conducted at the oblast and national level using data provided by the country's National Institute of Geography (NIG) and the National Tuberculosis Program (NTP). Reported incident case notification rates (CNRs) and prevalence vary by oblast, thus the study investigated which determinants contributed to this regional variation and compared burdens among oblasts.Results: The results showed that while tuberculosis CNRs decreased over the study period, MDR-TB conversely increased. Two oblasts -Atyrauskaya and Mangystauskaya - presented especially significant anomalies with large decreases in TB incident CNRs coupled with comparatively large increases in MDR-TB incident CNRs.Conclusion: Understanding the distribution of TB and MDR-TB cases and associated risk factors, especially the " unknown risk factor" categorization points to the need for future research.
AB - Background: Development of tuberculosis (TB) is determined by various risk factors and the interactions of temporal and spatial distributions. The aim of this study was to identify the most salient risk factors for TB disease as well as multidrug resistant TB (MDR-TB) at the oblast (provincial) level in Kazakhstan.Methods: Correlational and descriptive analyses were conducted at the oblast and national level using data provided by the country's National Institute of Geography (NIG) and the National Tuberculosis Program (NTP). Reported incident case notification rates (CNRs) and prevalence vary by oblast, thus the study investigated which determinants contributed to this regional variation and compared burdens among oblasts.Results: The results showed that while tuberculosis CNRs decreased over the study period, MDR-TB conversely increased. Two oblasts -Atyrauskaya and Mangystauskaya - presented especially significant anomalies with large decreases in TB incident CNRs coupled with comparatively large increases in MDR-TB incident CNRs.Conclusion: Understanding the distribution of TB and MDR-TB cases and associated risk factors, especially the " unknown risk factor" categorization points to the need for future research.
KW - Case notification rate (CNR)
KW - Kazakhstan
KW - MDR-TB
KW - National tuberculosis program (NTP)
KW - Oblast
KW - Prevalence
KW - Risk factors
KW - Spatial distribution
KW - Surveillance
KW - Tuberculosis
UR - http://www.scopus.com/inward/record.url?scp=84867568625&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84867568625&partnerID=8YFLogxK
U2 - 10.1186/1471-2334-12-262
DO - 10.1186/1471-2334-12-262
M3 - Article
C2 - 23075260
AN - SCOPUS:84867568625
VL - 12
JO - BMC Infectious Diseases
JF - BMC Infectious Diseases
SN - 1471-2334
M1 - 262
ER -