Tumor infiltrating lymphocytes in pet rabbit mammary carcinomas: A study with relevance to comparative pathology

Sandra Schöniger, Sophie Degner, Qian Zhang, Claudia Schandelmaier, Heike Aupperle-Lellbach, Bharat Jasani, Heinz Adolf Schoon

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Tumor infiltrating lymphocytes (TILs) serve as prognostic biomarker in human breast cancer. Rabbits have the potential to act as animal model for human breast cancer, and close similarities exist between the rabbit and human immune system. The aim of this study is to characterize TILs in pet rabbit mammary carcinomas and to statistically correlate results with histological and immunohistochemical tumor characteristics. Microscopic evaluation of TILs was performed in hematoxylin and eosin stained sections of 107 rabbit mammary carcinomas according to international guidelines for human breast cancer. Data on histological features of malignancy, estrogen and progesterone receptor status and calponin expression were obtained from the data base. This study revealed a statistical association between stromal TILs in the central tumor (CT) and infiltrative margin. Higher maximal percentages of stromal TILs at the CT were statistically correlated with decreased mitotic count and lower tumor grade. An increased number of calponin positive tumor cells was statistically associated with a lower mitotic count and a higher percentage of stromal TILs. Results suggest that higher percentages of stromal TILs are useful biomarkers that may point toward a favorable prognosis in rabbit mammary carcinomas and support the concept of the use of rabbits for translational research.

Original languageEnglish
Article number1437
Pages (from-to)1-17
Number of pages17
JournalAnimals
Volume10
Issue number8
DOIs
Publication statusPublished - Aug 2020

Keywords

  • Animal model
  • Biomarker
  • Breast cancer
  • Comparative pathology
  • Light microscopy
  • Mammary carcinomas
  • Oryctolagus cuniculus
  • Pet rabbit
  • Translational medicine
  • Tumor infiltrating lymphocytes

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

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