Tumor Promoting Aspects of Senescence in Cancer Progression

Qing Yang, Yingqiu Xie, Lixia Miao

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)


Cancers induced by gene mutation, deletion, and genome instability might be related to aging. With similar pathways of aging but distinct functions, senescence at the cellular level is an irreversible arrest of cell cycle. Senescence has long been believed as a barrier to restrict tumor expansion. However, more and more evidence has been shown that senescence inducers regulate epithelial–mesenchymal transition, stem cell self-renewal, inflammatory response, crosstalk with the oncogenic bypass signaling, and conversion of oncogene to tumor suppressor. Here we will discuss the most recent findings of the oncogenic aspects of senescence which crosstalk with multiple pathways in cancer progression.

Original languageEnglish
Pages (from-to)452-458
Number of pages7
JournalCancer Investigation
Issue number9
Publication statusPublished - Oct 20 2016


  • cancer
  • Senescence

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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