Tyrosine kinase receptors in the control of epithelial growth and morphogenesis during development

Carmen Birchmeier, Eva Sonnenberg, K. Michael Weidner, Barbara Walter

Research output: Contribution to journalReview article

32 Citations (Scopus)

Abstract

The c‐ros, c‐met and c‐neu genes encode receptor‐type tyrosine kinases and were originally identified because of their oncogenic potential. However, recent progress in the analysis of these receptors and their respective ligands indicate that they do not mediate exclusively mitogenic signals. Rather, they can induce cell movement, differentiation or morphogenesis of epithelial cells in culture. Interestingly, the discussed receptors are expressed in embryonal epithelia, whereas direct and indirect evidence shows that the corresponding ligands are produced in mesenchymal cells. In development, signals given by mesenchymal cells are major driving forces for differentiation and morphogenesis of epithelia; embryonal epithelia are generally unable to differentiate without the appropriate mesenchymal factors. The observed activities of these receptor/ligand systems in cultured cells and their expression patterns indicate that they regulate epithelial differentiation and morphogenesis also during embryogenesis and suggest thus a molecular basis for mesenchymal epithelial interactions.

Original languageEnglish
Pages (from-to)185-190
Number of pages6
JournalBioEssays
Volume15
Issue number3
DOIs
Publication statusPublished - 1993
Externally publishedYes

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Receptor Protein-Tyrosine Kinases
Morphogenesis
Epithelium
Ligands
Growth
Cells
Protein-Tyrosine Kinases
Embryonic Development
Cell Movement
Cell Differentiation
Cultured Cells
Cell Culture Techniques
Genes
Epithelial Cells

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Tyrosine kinase receptors in the control of epithelial growth and morphogenesis during development. / Birchmeier, Carmen; Sonnenberg, Eva; Weidner, K. Michael; Walter, Barbara.

In: BioEssays, Vol. 15, No. 3, 1993, p. 185-190.

Research output: Contribution to journalReview article

Birchmeier, Carmen ; Sonnenberg, Eva ; Weidner, K. Michael ; Walter, Barbara. / Tyrosine kinase receptors in the control of epithelial growth and morphogenesis during development. In: BioEssays. 1993 ; Vol. 15, No. 3. pp. 185-190.
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