Ultimobranchial body nests in human fetal thyroid: An autopsy, histological, and immunohistochemical study in relation to solid cell nests and mucoepidermoid carcinoma of the thyroid

H. R. Harach, G. M. Vujanić, B. Jasani

Research output: Contribution to journalArticlepeer-review

44 Citations (Scopus)

Abstract

The mid portion of the lateral thyroid lobes from 64 fetuses was systematically analysed for the presence of ultimobranchial body nests. The nests showed a prevalence of 1 /24 (4.2 per cent) or 13/40 (32.5 per cent) depending on whether a single‐ or a multi‐step sectioning method was employed, respectively, and showed anatomical, morphological, and histochemical features similar to those of ultimobranchial postnatal thyroid solid cell nests. Histochemical studies revealed the presence of mucosubstances in 73 per cent of the cases, calcitonin‐immunoreactive cells in 36 per cent, and both carcinoembryonic antigen and high‐molecular‐weight cytokeratin‐immunoreactive epidermoid cells in 85.7 per cent, respectively. These findings indicate that these markers, which are also expressed by solid cell nests of the thyroid, are of value for the detection and tracing of ultimobranchial tissue to earlier stages of development. The findings of this study support the hypothesis that mucoepidermoid carcinomas of the thyroid are of ultimobranchial tissue origin.

Original languageEnglish
Pages (from-to)465-469
Number of pages5
JournalThe Journal of Pathology
Volume169
Issue number4
DOIs
Publication statusPublished - Apr 1993

Keywords

  • C cells
  • Ultimobranchial body
  • fetal thyroid
  • histochemistry, solid cell nests
  • mucoepidermoid carcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Fingerprint Dive into the research topics of 'Ultimobranchial body nests in human fetal thyroid: An autopsy, histological, and immunohistochemical study in relation to solid cell nests and mucoepidermoid carcinoma of the thyroid'. Together they form a unique fingerprint.

Cite this