Ultrafine PEG-capped gadolinia nanoparticles

Cytotoxicity and potential biomedical applications for MRI and luminescent imaging

Timur Sh Atabaev, Jong Ho Lee, Dong Wook Han, Hyung Kook Kim, Yoon Hwae Hwang

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

In recent years, magnetic and luminescent nanoparticles (NPs) have attracted considerable attention because of their potential applications in nanomedicine. In this study, bimodal ultrafine polyethylene glycol (PEG)-capped gadolinium oxide NPs doped with erbium ions, which combine both paramagnetic and luminescent properties in a single entity, were synthesized using the urea homogeneous precipitation route. The morphological, chemical and structural properties of the synthesized particles were examined using a range of microscopy and energy-dispersive X-ray techniques. The optical characteristics of the gadolinium oxide NPs were examined by analyzing the room temperature emission spectra, which correspond to various manifold transitions of Er 3+. Pilot studies were performed to examine the cytotoxicity and capability of the synthesized NPs for the luminescent labeling of living C2C12 myoblastic cells. The paramagnetic properties of the synthesized particles as a magnetic resonance imaging MRI contrast agent were also assessed. Overall, these synthesized ultrafine PEG-coated Gd2O3:Er3+ NPs can potentially be used in biomedical applications because of their strong positive contrast enhancement in T1-weighted imaging, and intense green emission with near-infrared (NIR, 980 nm) excitation. This journal is

Original languageEnglish
Pages (from-to)34343-34349
Number of pages7
JournalRSC Advances
Volume4
Issue number65
DOIs
Publication statusPublished - 2014
Externally publishedYes

Fingerprint

Gadolinium
Cytotoxicity
Magnetic resonance imaging
Polyethylene glycols
Nanoparticles
Imaging techniques
Erbium
Medical nanotechnology
Oxides
Magnetic resonance
Urea
Labeling
Chemical properties
Contrast Media
Structural properties
Microscopic examination
Ultrafine
gadolinium oxide
Ions
Infrared radiation

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Chemistry(all)

Cite this

Ultrafine PEG-capped gadolinia nanoparticles : Cytotoxicity and potential biomedical applications for MRI and luminescent imaging. / Atabaev, Timur Sh; Lee, Jong Ho; Han, Dong Wook; Kim, Hyung Kook; Hwang, Yoon Hwae.

In: RSC Advances, Vol. 4, No. 65, 2014, p. 34343-34349.

Research output: Contribution to journalArticle

Atabaev, Timur Sh ; Lee, Jong Ho ; Han, Dong Wook ; Kim, Hyung Kook ; Hwang, Yoon Hwae. / Ultrafine PEG-capped gadolinia nanoparticles : Cytotoxicity and potential biomedical applications for MRI and luminescent imaging. In: RSC Advances. 2014 ; Vol. 4, No. 65. pp. 34343-34349.
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