Abstract
Skin dendritic cells (DCs) are divided into several subsets with distinctive functions. This study shows a previously unappreciated role of dermal CD11b-type Langerin(-) DCs in maintaining immunological self-tolerance after UVB exposure. After UVB exposure, dermal CD11b-type Langerin(-) DCs upregulated surface CD86 expression, induced proliferation of Foxp3(+) regulatory T (Treg) cells without exogenous Ags, and upregulated a set of genes associated with immunological tolerance. This Treg-expansion activity was significantly hampered by CD80/CD86 blockade in vivo. These results indicate that CD11b-type Langerin(-) DCs from the UVB-exposed skin are specialized to expand Treg cells in the skin, which suppress autoimmunity.
Original language | English |
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Number of pages | 11 |
Journal | Journal of Immunology |
DOIs | |
Publication status | E-pub ahead of print - Nov 20 2017 |
Externally published | Yes |
Keywords
- Journal Article