Abstract
Skin dendritic cells (DCs) are divided into several subsets with distinctive functions. This study shows a previously unappreciated role of dermal CD11b-type Langerin(-) DCs in maintaining immunological self-tolerance after UVB exposure. After UVB exposure, dermal CD11b-type Langerin(-) DCs upregulated surface CD86 expression, induced proliferation of Foxp3(+) regulatory T (Treg) cells without exogenous Ags, and upregulated a set of genes associated with immunological tolerance. This Treg-expansion activity was significantly hampered by CD80/CD86 blockade in vivo. These results indicate that CD11b-type Langerin(-) DCs from the UVB-exposed skin are specialized to expand Treg cells in the skin, which suppress autoimmunity.
| Original language | English |
|---|---|
| Number of pages | 11 |
| Journal | Journal of Immunology |
| DOIs | |
| Publication status | E-pub ahead of print - Nov 20 2017 |
| Externally published | Yes |
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Keywords
- Journal Article
Cite this
Ultraviolet B-Induced Maturation of CD11b-Type Langerin(-) Dendritic Cells Controls the Expansion of Foxp3(+) Regulatory T Cells in the Skin. / Yamazaki, Sayuri; Odanaka, Mizuyu; Nishioka, Akiko; Kasuya, Saori; Shime, Hiroaki; Hemmi, Hiroaki; Imai, Masaki; Riethmacher, Dieter; Kaisho, Tsuneyasu; Ohkura, Naganari; Sakaguchi, Shimon; Morita, Akimichi.
In: Journal of Immunology, 20.11.2017.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Ultraviolet B-Induced Maturation of CD11b-Type Langerin(-) Dendritic Cells Controls the Expansion of Foxp3(+) Regulatory T Cells in the Skin
AU - Yamazaki, Sayuri
AU - Odanaka, Mizuyu
AU - Nishioka, Akiko
AU - Kasuya, Saori
AU - Shime, Hiroaki
AU - Hemmi, Hiroaki
AU - Imai, Masaki
AU - Riethmacher, Dieter
AU - Kaisho, Tsuneyasu
AU - Ohkura, Naganari
AU - Sakaguchi, Shimon
AU - Morita, Akimichi
N1 - Copyright © 2017 by The American Association of Immunologists, Inc.
PY - 2017/11/20
Y1 - 2017/11/20
N2 - Skin dendritic cells (DCs) are divided into several subsets with distinctive functions. This study shows a previously unappreciated role of dermal CD11b-type Langerin(-) DCs in maintaining immunological self-tolerance after UVB exposure. After UVB exposure, dermal CD11b-type Langerin(-) DCs upregulated surface CD86 expression, induced proliferation of Foxp3(+) regulatory T (Treg) cells without exogenous Ags, and upregulated a set of genes associated with immunological tolerance. This Treg-expansion activity was significantly hampered by CD80/CD86 blockade in vivo. These results indicate that CD11b-type Langerin(-) DCs from the UVB-exposed skin are specialized to expand Treg cells in the skin, which suppress autoimmunity.
AB - Skin dendritic cells (DCs) are divided into several subsets with distinctive functions. This study shows a previously unappreciated role of dermal CD11b-type Langerin(-) DCs in maintaining immunological self-tolerance after UVB exposure. After UVB exposure, dermal CD11b-type Langerin(-) DCs upregulated surface CD86 expression, induced proliferation of Foxp3(+) regulatory T (Treg) cells without exogenous Ags, and upregulated a set of genes associated with immunological tolerance. This Treg-expansion activity was significantly hampered by CD80/CD86 blockade in vivo. These results indicate that CD11b-type Langerin(-) DCs from the UVB-exposed skin are specialized to expand Treg cells in the skin, which suppress autoimmunity.
KW - Journal Article
U2 - 10.4049/jimmunol.1701056
DO - 10.4049/jimmunol.1701056
M3 - Article
JO - Journal of Immunology
JF - Journal of Immunology
SN - 0022-1767
ER -