Ultraviolet B-Induced Maturation of CD11b-Type Langerin(-) Dendritic Cells Controls the Expansion of Foxp3(+) Regulatory T Cells in the Skin

Sayuri Yamazaki; Mizuyu Odanaka; Akiko Nishioka; Saori Kasuya; Hiroaki Shime; Hiroaki Hemmi; Masaki Imai; Dieter Riethmacher; Tsuneyasu Kaisho; Naganari Ohkura; Shimon Sakaguchi; Akimichi Morita

doi:10.4049/jimmunol.1701056

Ultraviolet B-Induced Maturation of CD11b-Type Langerin(-) Dendritic Cells Controls the Expansion of Foxp3(+) Regulatory T Cells in the Skin

Sayuri Yamazaki, Mizuyu Odanaka, Akiko Nishioka, Saori Kasuya, Hiroaki Shime, Hiroaki Hemmi, Masaki Imai, Dieter Riethmacher, Tsuneyasu Kaisho, Naganari Ohkura, Shimon Sakaguchi, Akimichi Morita

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Skin dendritic cells (DCs) are divided into several subsets with distinctive functions. This study shows a previously unappreciated role of dermal CD11b-type Langerin(-) DCs in maintaining immunological self-tolerance after UVB exposure. After UVB exposure, dermal CD11b-type Langerin(-) DCs upregulated surface CD86 expression, induced proliferation of Foxp3(+) regulatory T (Treg) cells without exogenous Ags, and upregulated a set of genes associated with immunological tolerance. This Treg-expansion activity was significantly hampered by CD80/CD86 blockade in vivo. These results indicate that CD11b-type Langerin(-) DCs from the UVB-exposed skin are specialized to expand Treg cells in the skin, which suppress autoimmunity.

Original language	English
Number of pages	11
Journal	Journal of Immunology
DOIs	https://doi.org/10.4049/jimmunol.1701056
Publication status	E-pub ahead of print - Nov 20 2017
Externally published	Yes

Keywords

Journal Article

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10.4049/jimmunol.1701056

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Ultraviolet B-Induced Maturation of CD11b-Type Langerin(-) Dendritic Cells Controls the Expansion of Foxp3(+) Regulatory T Cells in the Skin. / Yamazaki, Sayuri; Odanaka, Mizuyu; Nishioka, Akiko; Kasuya, Saori; Shime, Hiroaki; Hemmi, Hiroaki; Imai, Masaki; Riethmacher, Dieter; Kaisho, Tsuneyasu; Ohkura, Naganari; Sakaguchi, Shimon; Morita, Akimichi.

In: Journal of Immunology, 20.11.2017.

Research output: Contribution to journal › Article › peer-review

Yamazaki, Sayuri ; Odanaka, Mizuyu ; Nishioka, Akiko ; Kasuya, Saori ; Shime, Hiroaki ; Hemmi, Hiroaki ; Imai, Masaki ; Riethmacher, Dieter ; Kaisho, Tsuneyasu ; Ohkura, Naganari ; Sakaguchi, Shimon ; Morita, Akimichi. / Ultraviolet B-Induced Maturation of CD11b-Type Langerin(-) Dendritic Cells Controls the Expansion of Foxp3(+) Regulatory T Cells in the Skin. In: Journal of Immunology. 2017.

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abstract = "Skin dendritic cells (DCs) are divided into several subsets with distinctive functions. This study shows a previously unappreciated role of dermal CD11b-type Langerin(-) DCs in maintaining immunological self-tolerance after UVB exposure. After UVB exposure, dermal CD11b-type Langerin(-) DCs upregulated surface CD86 expression, induced proliferation of Foxp3(+) regulatory T (Treg) cells without exogenous Ags, and upregulated a set of genes associated with immunological tolerance. This Treg-expansion activity was significantly hampered by CD80/CD86 blockade in vivo. These results indicate that CD11b-type Langerin(-) DCs from the UVB-exposed skin are specialized to expand Treg cells in the skin, which suppress autoimmunity.",

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AU - Yamazaki, Sayuri

AU - Odanaka, Mizuyu

AU - Nishioka, Akiko

AU - Kasuya, Saori

AU - Shime, Hiroaki

AU - Hemmi, Hiroaki

AU - Imai, Masaki

AU - Riethmacher, Dieter

AU - Kaisho, Tsuneyasu

AU - Ohkura, Naganari

AU - Sakaguchi, Shimon

AU - Morita, Akimichi

PY - 2017/11/20

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N2 - Skin dendritic cells (DCs) are divided into several subsets with distinctive functions. This study shows a previously unappreciated role of dermal CD11b-type Langerin(-) DCs in maintaining immunological self-tolerance after UVB exposure. After UVB exposure, dermal CD11b-type Langerin(-) DCs upregulated surface CD86 expression, induced proliferation of Foxp3(+) regulatory T (Treg) cells without exogenous Ags, and upregulated a set of genes associated with immunological tolerance. This Treg-expansion activity was significantly hampered by CD80/CD86 blockade in vivo. These results indicate that CD11b-type Langerin(-) DCs from the UVB-exposed skin are specialized to expand Treg cells in the skin, which suppress autoimmunity.

AB - Skin dendritic cells (DCs) are divided into several subsets with distinctive functions. This study shows a previously unappreciated role of dermal CD11b-type Langerin(-) DCs in maintaining immunological self-tolerance after UVB exposure. After UVB exposure, dermal CD11b-type Langerin(-) DCs upregulated surface CD86 expression, induced proliferation of Foxp3(+) regulatory T (Treg) cells without exogenous Ags, and upregulated a set of genes associated with immunological tolerance. This Treg-expansion activity was significantly hampered by CD80/CD86 blockade in vivo. These results indicate that CD11b-type Langerin(-) DCs from the UVB-exposed skin are specialized to expand Treg cells in the skin, which suppress autoimmunity.

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