Understanding the Pathogenesis of Spondyloarthritis.

Aigul Sharip, Jeannette Kunz

Research output: Contribution to journalArticle

Abstract

Spondyloarthritis comprises of a group of inflammatory diseases of the joints and spine with various clinical manifestations. The group includes ankylosing spondylitis, reactive arthritis, psoriatic arthritis, arthritis associated with inflammatory bowel disease, and undifferentiated spondyloarthritis. The exact etiology and pathogenesis of spondyloarthritis are still unknown, but five hypotheses explaining the pathogenesis exist. These hypotheses suggest that spondyloarthritis is caused by arthritogenic peptides, an unfolded protein response, HLA-B27 homodimer formation, malfunctioning endoplasmic reticulum aminopeptidases, and, last but not least, gut inflammation and dysbiosis. Here we discuss the five hypotheses and the evidence supporting each. In all of these hypotheses, HLA-B27 plays a central role. It is likely that a combination of these hypotheses, with HLA-B27 taking center stage, will eventually explain the development of spondyloarthritis in predisposed individuals.
Original languageEnglish
JournalBiomolecules
Publication statusAccepted/In press - Sep 8 2020

Fingerprint Dive into the research topics of 'Understanding the Pathogenesis of Spondyloarthritis.'. Together they form a unique fingerprint.

Cite this