Unprecedented Cu(I)-catalyzed microwave-assisted three-component coupling of a ketone, an alkyne, and a primary amine

Olga P. Pereshivko; Vsevolod A. Peshkov; Erik V. Van Der Eycken

doi:10.1021/ol1008312

Unprecedented Cu(I)-catalyzed microwave-assisted three-component coupling of a ketone, an alkyne, and a primary amine

Olga P. Pereshivko, Vsevolod A. Peshkov, Erik V. Van Der Eycken

Research output: Contribution to journal › Article › peer-review

77 Citations (Scopus)

Abstract

An efficient, microwave-assisted Cu(I)-catalyzed one-pot coupling of a ketone, an alkyne, and a primary amine (KA² coupling) is described, giving access to secondary propargylamines.

Original language	English
Pages (from-to)	2638-2641
Number of pages	4
Journal	Organic Letters
Volume	12
Issue number	11
DOIs	https://doi.org/10.1021/ol1008312
Publication status	Published - Jun 4 2010
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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title = "Unprecedented Cu(I)-catalyzed microwave-assisted three-component coupling of a ketone, an alkyne, and a primary amine",

abstract = "An efficient, microwave-assisted Cu(I)-catalyzed one-pot coupling of a ketone, an alkyne, and a primary amine (KA2 coupling) is described, giving access to secondary propargylamines.",

author = "Pereshivko, {Olga P.} and Peshkov, {Vsevolod A.} and {Van Der Eycken}, {Erik V.}",

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AU - Pereshivko, Olga P.

AU - Peshkov, Vsevolod A.

AU - Van Der Eycken, Erik V.

PY - 2010/6/4

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AB - An efficient, microwave-assisted Cu(I)-catalyzed one-pot coupling of a ketone, an alkyne, and a primary amine (KA2 coupling) is described, giving access to secondary propargylamines.

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