Unprecedented Cu(I)-catalyzed microwave-assisted three-component coupling of a ketone, an alkyne, and a primary amine

Olga P. Pereshivko, Vsevolod A. Peshkov, Erik V. Van Der Eycken

Research output: Contribution to journalArticlepeer-review

77 Citations (Scopus)

Abstract

An efficient, microwave-assisted Cu(I)-catalyzed one-pot coupling of a ketone, an alkyne, and a primary amine (KA2 coupling) is described, giving access to secondary propargylamines.

Original languageEnglish
Pages (from-to)2638-2641
Number of pages4
JournalOrganic Letters
Volume12
Issue number11
DOIs
Publication statusPublished - Jun 4 2010
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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