V1 spinal neurons regulate the speed of vertebrate locomotor outputs

Simon Gosgnach, Guillermo M. Lanuza, Simon J B Butt, Harald Saueressig, Ying Zhang, Tomoko Velasquez, Dieter Riethmacher, Edward M. Callaway, Ole Kiehn, Martyn Goulding

Research output: Contribution to journalArticle

233 Citations (Scopus)

Abstract

The neuronal networks that generate vertebrate movements such as walking and swimming are embedded in the spinal cord1-3. These networks, which are referred to as central pattern generators (CPGs), are ideal systems for determining how ensembles of neurons generate simple behavioural outputs. In spite of efforts to address the organization of the locomotor CPG in walking animals2,4-6, little is known about the identity and function of the spinal interneuron cell types that contribute to these locomotor networks. Here we use four complementary genetic approaches to directly address the function of mouse V1 neurons, a class of local circuit inhibitory interneurons that selectively express the transcription factor Engrailedl. Our results show that V1 neurons shape motor outputs during locomotion and are required for generating 'fast' motor bursting. These findings outline an important role for inhibition in regulating the frequency of the locomotor CPG rhythm, and also suggest that V1 neurons may have an evolutionarily conserved role in controlling the speed of vertebrate locomotor movements.

Original languageEnglish
Pages (from-to)215-219
Number of pages5
JournalNature
Volume440
Issue number7081
DOIs
Publication statusPublished - Mar 9 2006
Externally publishedYes

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Central Pattern Generators
Vertebrates
Interneurons
Neurons
Walking
Motor Neurons
Locomotion
Transcription Factors

ASJC Scopus subject areas

  • General

Cite this

Gosgnach, S., Lanuza, G. M., Butt, S. J. B., Saueressig, H., Zhang, Y., Velasquez, T., ... Goulding, M. (2006). V1 spinal neurons regulate the speed of vertebrate locomotor outputs. Nature, 440(7081), 215-219. https://doi.org/10.1038/nature04545

V1 spinal neurons regulate the speed of vertebrate locomotor outputs. / Gosgnach, Simon; Lanuza, Guillermo M.; Butt, Simon J B; Saueressig, Harald; Zhang, Ying; Velasquez, Tomoko; Riethmacher, Dieter; Callaway, Edward M.; Kiehn, Ole; Goulding, Martyn.

In: Nature, Vol. 440, No. 7081, 09.03.2006, p. 215-219.

Research output: Contribution to journalArticle

Gosgnach, S, Lanuza, GM, Butt, SJB, Saueressig, H, Zhang, Y, Velasquez, T, Riethmacher, D, Callaway, EM, Kiehn, O & Goulding, M 2006, 'V1 spinal neurons regulate the speed of vertebrate locomotor outputs', Nature, vol. 440, no. 7081, pp. 215-219. https://doi.org/10.1038/nature04545
Gosgnach S, Lanuza GM, Butt SJB, Saueressig H, Zhang Y, Velasquez T et al. V1 spinal neurons regulate the speed of vertebrate locomotor outputs. Nature. 2006 Mar 9;440(7081):215-219. https://doi.org/10.1038/nature04545
Gosgnach, Simon ; Lanuza, Guillermo M. ; Butt, Simon J B ; Saueressig, Harald ; Zhang, Ying ; Velasquez, Tomoko ; Riethmacher, Dieter ; Callaway, Edward M. ; Kiehn, Ole ; Goulding, Martyn. / V1 spinal neurons regulate the speed of vertebrate locomotor outputs. In: Nature. 2006 ; Vol. 440, No. 7081. pp. 215-219.
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