Vaccination and autoimmune diseases: is prevention of adverse health effects on the horizon?

Maria Vadalà, Dimitri Poddighe, Carmen Laurino, Beniamino Palmieri

Research output: Contribution to journalReview articlepeer-review

10 Citations (Scopus)

Abstract

Autoimmune diseases, including multiple sclerosis and type 1 diabetes mellitus, affect about 5% of the worldwide population. In the last decade, reports have accumulated on various autoimmune disorders, such as idiopathic thrombocytopenia purpura, myopericarditis, primary ovarian failure, and systemic lupus erythematosus (SLE), following vaccination. In this review, we discuss the possible underlying mechanisms of autoimmune reactions following vaccinations and review cases of autoimmune diseases that have been correlated with vaccination. Molecular mimicry and bystander activation are reported as possible mechanisms by which vaccines can cause autoimmune reactions. The individuals who might be susceptible to develop these reactions could be especially not only those with previous post-vaccination phenomena and those with allergies but also in individuals who are prone to develop autoimmune diseases, such as those with a family history of autoimmunity or with known autoantibodies, and the genetic predisposed individuals. Further research is encouraged into the direct associations between vaccines and autoimmune conditions, and the biological mechanisms behind them.

Original languageEnglish
Pages (from-to)295-311
Number of pages17
JournalEPMA Journal
Volume8
Issue number3
DOIs
Publication statusPublished - Jul 20 2017
Externally publishedYes

Keywords

  • Diabetes
  • Genetic test
  • Individualized patient profile
  • Multiple sclerosis
  • Predictive preventive personalized medicine
  • Vaccine

ASJC Scopus subject areas

  • Drug Discovery
  • Health Policy
  • Biochemistry, medical

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