Abstract
In pharmaceutical industries, most active pharmaceutical ingredients are poorly water soluble, and therefore milling processes are important to obtain fine particles that can be easily dissolved in the body. However, the main purpose of milling is micronization of particles. From the viewpoint of fine particle preparation in the formulation process, milling has not been investigated sufficiently. In this paper, ethenzamide was milled under various operating conditions using a fluidized-bed jet-mill. It was found that not only the particle size but also the particle shape varied with the milling conditions. The relationship between particle shape and milling conditions has been obtained experimentally.
| Original language | English |
|---|---|
| Pages (from-to) | 951-957 |
| Number of pages | 7 |
| Journal | Yakugaku Zasshi |
| Volume | 125 |
| Issue number | 12 |
| Publication status | Published - Dec 2005 |
| Externally published | Yes |
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Keywords
- Active pharmaceutical ingredient
- Ethenzamide
- Fluidized-bed jet-mill
- Operating condition
- Particle shape
ASJC Scopus subject areas
- Molecular Medicine
Cite this
Variation in particle shape of active pharmaceutical ingredients prepared by fluidized-bed jet-milling. / Fukunaka, Tadashi; Sawaguchi, Kohta; Golman, Boris; Shinohara, Kunio.
In: Yakugaku Zasshi, Vol. 125, No. 12, 12.2005, p. 951-957.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Variation in particle shape of active pharmaceutical ingredients prepared by fluidized-bed jet-milling
AU - Fukunaka, Tadashi
AU - Sawaguchi, Kohta
AU - Golman, Boris
AU - Shinohara, Kunio
PY - 2005/12
Y1 - 2005/12
N2 - In pharmaceutical industries, most active pharmaceutical ingredients are poorly water soluble, and therefore milling processes are important to obtain fine particles that can be easily dissolved in the body. However, the main purpose of milling is micronization of particles. From the viewpoint of fine particle preparation in the formulation process, milling has not been investigated sufficiently. In this paper, ethenzamide was milled under various operating conditions using a fluidized-bed jet-mill. It was found that not only the particle size but also the particle shape varied with the milling conditions. The relationship between particle shape and milling conditions has been obtained experimentally.
AB - In pharmaceutical industries, most active pharmaceutical ingredients are poorly water soluble, and therefore milling processes are important to obtain fine particles that can be easily dissolved in the body. However, the main purpose of milling is micronization of particles. From the viewpoint of fine particle preparation in the formulation process, milling has not been investigated sufficiently. In this paper, ethenzamide was milled under various operating conditions using a fluidized-bed jet-mill. It was found that not only the particle size but also the particle shape varied with the milling conditions. The relationship between particle shape and milling conditions has been obtained experimentally.
KW - Active pharmaceutical ingredient
KW - Ethenzamide
KW - Fluidized-bed jet-mill
KW - Operating condition
KW - Particle shape
UR - http://www.scopus.com/inward/record.url?scp=28544447104&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=28544447104&partnerID=8YFLogxK
M3 - Review article
VL - 125
SP - 951
EP - 957
JO - Yakugaku Zasshi
JF - Yakugaku Zasshi
SN - 0031-6903
IS - 12
ER -