Abstract
In pharmaceutical industries, most active pharmaceutical ingredients are poorly water soluble, and therefore milling processes are important to obtain fine particles that can be easily dissolved in the body. However, the main purpose of milling is micronization of particles. From the viewpoint of fine particle preparation in the formulation process, milling has not been investigated sufficiently. In this paper, ethenzamide was milled under various operating conditions using a fluidized-bed jet-mill. It was found that not only the particle size but also the particle shape varied with the milling conditions. The relationship between particle shape and milling conditions has been obtained experimentally.
| Original language | English |
|---|---|
| Pages (from-to) | 951-957 |
| Number of pages | 7 |
| Journal | Yakugaku Zasshi |
| Volume | 125 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - Dec 2005 |
Keywords
- Active pharmaceutical ingredient
- Ethenzamide
- Fluidized-bed jet-mill
- Operating condition
- Particle shape
ASJC Scopus subject areas
- Pharmacology
- Pharmaceutical Science
Fingerprint Dive into the research topics of 'Variation in particle shape of active pharmaceutical ingredients prepared by fluidized-bed jet-milling'. Together they form a unique fingerprint.
Cite this
Fukunaka, T., Sawaguchi, K., Golman, B., & Shinohara, K. (2005). Variation in particle shape of active pharmaceutical ingredients prepared by fluidized-bed jet-milling. Yakugaku Zasshi, 125(12), 951-957. https://doi.org/10.1248/yakushi.125.951