Variation in particle shape of active pharmaceutical ingredients prepared by fluidized-bed jet-milling

Tadashi Fukunaka; Kohta Sawaguchi; Boris Golman; Kunio Shinohara

doi:10.1248/yakushi.125.951

Variation in particle shape of active pharmaceutical ingredients prepared by fluidized-bed jet-milling

Tadashi Fukunaka, Kohta Sawaguchi, Boris Golman, Kunio Shinohara

Department of Chemical and Materials Engineering

Research output: Contribution to journal › Review article › peer-review

1 Citation (Scopus)

Abstract

In pharmaceutical industries, most active pharmaceutical ingredients are poorly water soluble, and therefore milling processes are important to obtain fine particles that can be easily dissolved in the body. However, the main purpose of milling is micronization of particles. From the viewpoint of fine particle preparation in the formulation process, milling has not been investigated sufficiently. In this paper, ethenzamide was milled under various operating conditions using a fluidized-bed jet-mill. It was found that not only the particle size but also the particle shape varied with the milling conditions. The relationship between particle shape and milling conditions has been obtained experimentally.

Original language	English
Pages (from-to)	951-957
Number of pages	7
Journal	Yakugaku Zasshi
Volume	125
Issue number	12
DOIs	https://doi.org/10.1248/yakushi.125.951
Publication status	Published - Dec 2005

Keywords

Active pharmaceutical ingredient
Ethenzamide
Fluidized-bed jet-mill
Operating condition
Particle shape

ASJC Scopus subject areas

Pharmacology
Pharmaceutical Science

Access to Document

10.1248/yakushi.125.951

Fingerprint Dive into the research topics of 'Variation in particle shape of active pharmaceutical ingredients prepared by fluidized-bed jet-milling'. Together they form a unique fingerprint.

Cite this

@article{44c5e311c85d46c29f5bc55f5c02f047,

title = "Variation in particle shape of active pharmaceutical ingredients prepared by fluidized-bed jet-milling",

abstract = "In pharmaceutical industries, most active pharmaceutical ingredients are poorly water soluble, and therefore milling processes are important to obtain fine particles that can be easily dissolved in the body. However, the main purpose of milling is micronization of particles. From the viewpoint of fine particle preparation in the formulation process, milling has not been investigated sufficiently. In this paper, ethenzamide was milled under various operating conditions using a fluidized-bed jet-mill. It was found that not only the particle size but also the particle shape varied with the milling conditions. The relationship between particle shape and milling conditions has been obtained experimentally.",

keywords = "Active pharmaceutical ingredient, Ethenzamide, Fluidized-bed jet-mill, Operating condition, Particle shape",

author = "Tadashi Fukunaka and Kohta Sawaguchi and Boris Golman and Kunio Shinohara",

year = "2005",

month = dec,

doi = "10.1248/yakushi.125.951",

language = "English",

volume = "125",

pages = "951--957",

journal = "Yakugaku Zasshi",

issn = "0031-6903",

publisher = "Pharmaceutical Society of Japan",

number = "12",

}

TY - JOUR

T1 - Variation in particle shape of active pharmaceutical ingredients prepared by fluidized-bed jet-milling

AU - Fukunaka, Tadashi

AU - Sawaguchi, Kohta

AU - Golman, Boris

AU - Shinohara, Kunio

PY - 2005/12

Y1 - 2005/12

N2 - In pharmaceutical industries, most active pharmaceutical ingredients are poorly water soluble, and therefore milling processes are important to obtain fine particles that can be easily dissolved in the body. However, the main purpose of milling is micronization of particles. From the viewpoint of fine particle preparation in the formulation process, milling has not been investigated sufficiently. In this paper, ethenzamide was milled under various operating conditions using a fluidized-bed jet-mill. It was found that not only the particle size but also the particle shape varied with the milling conditions. The relationship between particle shape and milling conditions has been obtained experimentally.

AB - In pharmaceutical industries, most active pharmaceutical ingredients are poorly water soluble, and therefore milling processes are important to obtain fine particles that can be easily dissolved in the body. However, the main purpose of milling is micronization of particles. From the viewpoint of fine particle preparation in the formulation process, milling has not been investigated sufficiently. In this paper, ethenzamide was milled under various operating conditions using a fluidized-bed jet-mill. It was found that not only the particle size but also the particle shape varied with the milling conditions. The relationship between particle shape and milling conditions has been obtained experimentally.

KW - Active pharmaceutical ingredient

KW - Ethenzamide

KW - Fluidized-bed jet-mill

KW - Operating condition

KW - Particle shape

UR - http://www.scopus.com/inward/record.url?scp=28544447104&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=28544447104&partnerID=8YFLogxK

U2 - 10.1248/yakushi.125.951

DO - 10.1248/yakushi.125.951

M3 - Review article

C2 - 16327240

AN - SCOPUS:28544447104

VL - 125

SP - 951

EP - 957

JO - Yakugaku Zasshi

JF - Yakugaku Zasshi

SN - 0031-6903

IS - 12

ER -

Variation in particle shape of active pharmaceutical ingredients prepared by fluidized-bed jet-milling

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Cite this