Viability of glioblastoma stem cells is effectively reduced by diisothiocyanate-derived mercapturic acids

Kamila Cwiklowska, Mike-Andrew Westhoff, Simon Freisinger, Annika Dwucet, Marc-Eric Halatsch, Uwe Knippschild, Klaus-Michael Debatin, Reinhold Schirmbeck, Lukasz Winiarski, Jozef Oleksyszyn, Christian Rainer Wirtz, Timo Burster

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Glioblastoma is the most aggressive tumor of the central nervous system and is manifested by diffuse invasion of glioblastoma stem cells into the healthy tissue, chemoresistance and recurrence. Despite aggressive therapy, consisting of maximal surgical resection, radiotherapy and chemotherapy with temozolomide (Temodal®), life expectancy of patients with glioblastoma is typically less than 15 months. In general, natural isothiocyanates isolated from plants of the Cruciferae family are selectively cytotoxic to tumor cells. It has been demonstrated previously that diisothiocyanate-derived mercapturic acids are highly cytotoxic to colon cancer cells. In the present study, the application of diisothiocyanate-derived mercapturic acids led to a decrease in the viability of an established glioblastoma cell line, primary patient-derived sphere-cultured stem cell-enriched cell populations (SCs), and cells differentiated from SCs. Consequently, targeting glioblastoma cells by diisothiocyanate-derived mercapturic acids is a promising approach to restrict tumor cell growth and may be a novel therapeutic intervention for the treatment of glioblastoma.

Original languageEnglish
Pages (from-to)6181-6187
Number of pages7
JournalOncology Letters
Volume16
Issue number5
DOIs
Publication statusPublished - Nov 2018
Externally publishedYes

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