Vicenin-2 treatment attenuated the diethylnitrosamine-induced liver carcinoma and oxidative stress through increased apoptotic protein expression in experimental rats

Chunyang Zhang, Yuhui Chen, Ming Zhang, Chunni Xu, Guojin Gong, Vishnu Priya Veeraraghavan, Srinivasa Rao Bolla, Yandong Li

Research output: Contribution to journalArticlepeer-review

Abstract

Liver cancer or hepatocellular carcinoma is considered to be the third leading cause of death among all other cancers. The rate of liver cancer occurrence is high, and the rate of recovery is low. In this study, we investigated the therapeutic efficacy of vicenin-2 against the diethylnitrosamine-induced liver carcinoma in experimental rats. Diethylni-trosamine was widely employed as a carcinogenic agent to stimulate the cancer in animal models. Our results indicated that vicenin-2 administration effectively attenuates the diethylnitrosamine-induced physiological and pharmacological alterations in the experimental rats. Vicenin-2 treatment significantly enhanced the pathological lesions and decreased the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and α-fetoprotein (AFP) in serum. We also observed that vicenin-2 reduced the production of reactive oxygen species, decreased the liver weight, upregulated expression of apoptotic proteins, and decreased the histological changes in the liver, which are induced by the diethylnitrosamine in rats. Moreover, vicenin-2 downregulates antiapoptotic Bcl-2 and Bcl-xL, and upregulates the proapoptotic Bax and caspase. Hence, our results suggested that vicenin-2 had a highly therapeutic effect in reversing diethylnitrosamine-induced liver carcinoma in rats, which might be related to the apoptosis induced by vicenin-2. Therefore vicenin-2 could be a good candidate for future therapeutic use to inhibit chemically induced liver cancer.

Original languageEnglish
Pages (from-to)113-123
Number of pages11
JournalJournal of Environmental Pathology, Toxicology and Oncology
Volume39
Issue number2
DOIs
Publication statusPublished - 2020

Keywords

  • Apoptosis
  • Diethylnitrosamine
  • Hepatocellular carcinoma
  • ROS
  • Vicenin-2

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Toxicology
  • Health, Toxicology and Mutagenesis

Fingerprint Dive into the research topics of 'Vicenin-2 treatment attenuated the diethylnitrosamine-induced liver carcinoma and oxidative stress through increased apoptotic protein expression in experimental rats'. Together they form a unique fingerprint.

Cite this