Visualization tools for presenting and analysis of global landscapes of vaccine targets

Suresh Kalathur, Vladimir Brusic, Guang Lan Zhang, Lou Chitkushev, Tanya Zlateva

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Immunology produces large amounts of complex and hierarchical data. The overwhelming quantities and complexity of these data present a challenge for immunologists trying to interpret results, extract useful information, and derive new knowledge. Visualization plays an increasingly important role in the process of analyzing and understanding immunological data. We employed two visualization modules - heat map and stack graph, to be embedded in MULTIPRED2, a computational system for antigenic analysis and support of large-scale vaccine studies. We have described two complementary modules that display complex information on antigenic targets from proteins. The heat map enables visualization of large number of HLA variants, their groupings within the supertypes, and identification of antigenic regions within a query protein sequence. The stack graph is an interactive tool that presents predicted immunogenicity of a query protein across multiple HLA supertypes at human population level. The stack graph enables zooming in and out facilitating visualization at desired level of detail. Both visualization tools present a large amount of information in a single graphical display. The goal of visualization tools is to help immunologists and vaccine researchers to gain rapid insight into the data using comprehensive but clear graphic representation and summarization.

Original languageEnglish
Title of host publication2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2011
Pages683-688
Number of pages6
DOIs
Publication statusPublished - Dec 1 2011
Event2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2011 - Atlanta, GA, United States
Duration: Nov 12 2011Nov 15 2011

Publication series

Name2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2011

Other

Other2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2011
CountryUnited States
CityAtlanta, GA
Period11/12/1111/15/11

ASJC Scopus subject areas

  • Biomedical Engineering
  • Health Informatics
  • Health Information Management

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    Kalathur, S., Brusic, V., Zhang, G. L., Chitkushev, L., & Zlateva, T. (2011). Visualization tools for presenting and analysis of global landscapes of vaccine targets. In 2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2011 (pp. 683-688). [6112453] (2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2011). https://doi.org/10.1109/BIBMW.2011.6112453