Yin Yang 1 is a critical regulator of B-cell development

Huifei Liu, Marc Schmidt-Supprian, Yujiang Shi, Elias Hobeika, Natasha Barteneva, Hassan Jumaa, Roberta Pelanda, Michael Reth, Jane Skok, Klaus Rajewsky, Yang Shi

Research output: Contribution to journalArticlepeer-review

190 Citations (Scopus)


The role of the transcription factor Yin Yang 1 (YY1) in development is largely unknown. Here we show that specific ablation of YY1 in mouse B cells caused a defect in somatic rearrangement in the immunoglobulin heavy-chain (IgH) locus and a block in the progenitor-B-to-precursor-B-cell transition, which was partially rescued by a prerearranged IgH transgene. Three-dimensional DNA fluorescence in situ hybridization analysis revealed an important function for YY1 in IgH locus contraction, a process indispensable for distal VH to DHJH recombination. We provide evidence that YY1 binds the intronic Eiμ enhancer within the IgH locus, consistent with a direct role for YY1 in VHDHJH recombination. These findings identified YY1 as a critical regulator of early B-cell development.

Original languageEnglish
Pages (from-to)1179-1189
Number of pages11
JournalGenes and Development
Issue number10
Publication statusPublished - May 15 2007


  • B-cell development
  • Immunoglobulin gene
  • V(D)J recombination
  • YY1

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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