Artificial genetic polymers against human pathologies

Gleb S. Ivanov; Vyacheslav G. Tribulovich; Nikolay B. Pestov; Temitope I. David; Abdul Saleem Amoah; Tatyana V. Korneenko; Nikolai A. Barlev

doi:10.1186/s13062-022-00353-7

Artificial genetic polymers against human pathologies

Gleb S. Ivanov
, Vyacheslav G. Tribulovich
, Nikolay B. Pestov
, Temitope I. David
, Abdul Saleem Amoah
, Tatyana V. Korneenko
, Nikolai A. Barlev

RAS - Institute of Cytology
St. Petersburg State Institute of Technology
RAS - Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products
Moscow Institute of Physics and Technology
Russian Academy of Sciences
Russian Academy of Medical Sciences - Institute of Biomedical Chemistry
Nazarbayev University

Результат исследований › рецензирование

5 Цитирования (Scopus)

Аннотация

Originally discovered by Nielsen in 1991, peptide nucleic acids and other artificial genetic polymers have gained a lot of interest from the scientific community. Due to their unique biophysical features these artificial hybrid polymers are now being employed in various areas of theranostics (therapy and diagnostics). The current review provides an overview of their structure, principles of rational design, and biophysical features as well as highlights the areas of their successful implementation in biology and biomedicine. Finally, the review discusses the areas of improvement that would allow their use as a new class of therapeutics in the future.

Язык оригинала	English
Номер статьи	39
Журнал	Biology Direct
Том	17
Номер выпуска	1
DOI	https://doi.org/10.1186/s13062-022-00353-7
Состояние	Published - дек. 2022
Опубликовано для внешнего пользования	Да

ASJC Scopus subject areas

Immunology
Ecology, Evolution, Behavior and Systematics
Modelling and Simulation
General Biochemistry,Genetics and Molecular Biology
General Agricultural and Biological Sciences
Applied Mathematics

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title = "Artificial genetic polymers against human pathologies",

abstract = "Originally discovered by Nielsen in 1991, peptide nucleic acids and other artificial genetic polymers have gained a lot of interest from the scientific community. Due to their unique biophysical features these artificial hybrid polymers are now being employed in various areas of theranostics (therapy and diagnostics). The current review provides an overview of their structure, principles of rational design, and biophysical features as well as highlights the areas of their successful implementation in biology and biomedicine. Finally, the review discusses the areas of improvement that would allow their use as a new class of therapeutics in the future.",

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doi = "10.1186/s13062-022-00353-7",

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volume = "17",

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AU - Ivanov, Gleb S.

AU - Tribulovich, Vyacheslav G.

AU - Pestov, Nikolay B.

AU - David, Temitope I.

AU - Amoah, Abdul Saleem

AU - Korneenko, Tatyana V.

AU - Barlev, Nikolai A.

PY - 2022/12

Y1 - 2022/12

N2 - Originally discovered by Nielsen in 1991, peptide nucleic acids and other artificial genetic polymers have gained a lot of interest from the scientific community. Due to their unique biophysical features these artificial hybrid polymers are now being employed in various areas of theranostics (therapy and diagnostics). The current review provides an overview of their structure, principles of rational design, and biophysical features as well as highlights the areas of their successful implementation in biology and biomedicine. Finally, the review discusses the areas of improvement that would allow their use as a new class of therapeutics in the future.

AB - Originally discovered by Nielsen in 1991, peptide nucleic acids and other artificial genetic polymers have gained a lot of interest from the scientific community. Due to their unique biophysical features these artificial hybrid polymers are now being employed in various areas of theranostics (therapy and diagnostics). The current review provides an overview of their structure, principles of rational design, and biophysical features as well as highlights the areas of their successful implementation in biology and biomedicine. Finally, the review discusses the areas of improvement that would allow their use as a new class of therapeutics in the future.

KW - Locked nucleic acids

KW - Peptide nucleic acids

KW - Xenonucleic acids

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UR - https://www.scopus.com/pages/publications/85143548222#tab=citedBy

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DO - 10.1186/s13062-022-00353-7

M3 - Review article

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AN - SCOPUS:85143548222

SN - 1745-6150

VL - 17

JO - Biology Direct

JF - Biology Direct

IS - 1

M1 - 39

ER -

Artificial genetic polymers against human pathologies

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