TY - GEN
T1 - Effect of Barbiturate Coma Therapy on Patients with Resistant Intracranial Hypertension
T2 - 2023 International Conference on Decision Aid Sciences and Applications, DASA 2023
AU - Abdildin, Yerkin
AU - Jyeniskhan, Nursultan
AU - Salamat, Azamat
AU - Tungushpayev, Meiram
AU - Viderman, Dmitriy
N1 - Publisher Copyright:
© 2023 IEEE.
PY - 2023
Y1 - 2023
N2 - Increased intracranial pressure (ICP) after traumatic brain injury can lead to death of patients. This work aimed to evaluate the impact of barbiturate coma therapy (BCT) on intractable intracranial hypertension patients. We conducted a statistical analysis of studies published up to May 2023. The model showed a positive effect of BCT during treatment., the ICP in the experimental group of patients was 11.29 mmHg lower (on average) than in the control group (mean difference with 95% confidence interval is -11.29 [-16.19., -6.39], p-value < 0.00001). The model also showed a positive effect of BCT on the patient's neurological condition (MD with a 95% CI is 0.73 [0.37., 1.10]p-value < 0.0001). BCT significantly reduces intracranial pressure and improves the patient's neurological condition. Although our results are statistically significant, they are based on limited data from four clinical trials. Future studies may evaluate the possible side effects of BCT.
AB - Increased intracranial pressure (ICP) after traumatic brain injury can lead to death of patients. This work aimed to evaluate the impact of barbiturate coma therapy (BCT) on intractable intracranial hypertension patients. We conducted a statistical analysis of studies published up to May 2023. The model showed a positive effect of BCT during treatment., the ICP in the experimental group of patients was 11.29 mmHg lower (on average) than in the control group (mean difference with 95% confidence interval is -11.29 [-16.19., -6.39], p-value < 0.00001). The model also showed a positive effect of BCT on the patient's neurological condition (MD with a 95% CI is 0.73 [0.37., 1.10]p-value < 0.0001). BCT significantly reduces intracranial pressure and improves the patient's neurological condition. Although our results are statistically significant, they are based on limited data from four clinical trials. Future studies may evaluate the possible side effects of BCT.
KW - barbiturate infusion
KW - evidence-based medicine
KW - Glasgow outcome scale
KW - intractable intracranial hypertension
KW - medical decision making
UR - https://www.scopus.com/pages/publications/85177438120
UR - https://www.scopus.com/pages/publications/85177438120#tab=citedBy
U2 - 10.1109/DASA59624.2023.10286695
DO - 10.1109/DASA59624.2023.10286695
M3 - Conference contribution
AN - SCOPUS:85177438120
T3 - 2023 International Conference on Decision Aid Sciences and Applications, DASA 2023
SP - 485
EP - 488
BT - 2023 International Conference on Decision Aid Sciences and Applications, DASA 2023
PB - Institute of Electrical and Electronics Engineers Inc.
Y2 - 16 September 2023 through 17 September 2023
ER -