The Potential Role of Extracellular Vesicles in COVID-19 Treatment: Opportunity and Challenge

Yan Yan Yan; Wen Min Zhou; Yu Qing Wang; Qiao Ru Guo; Fu Xi Zhao; Zhuang Yan Zhu; Yan Xia Xing; Hai Yan Zhang; Mohamad Aljofan; Alireza Mosavi Jarrahi; Bolat Makabel; Jian Ye Zhang

doi:10.3389/fmolb.2021.699929

The Potential Role of Extracellular Vesicles in COVID-19 Treatment: Opportunity and Challenge

Yan Yan Yan
, Wen Min Zhou
, Yu Qing Wang
, Qiao Ru Guo
, Fu Xi Zhao
, Zhuang Yan Zhu
, Yan Xia Xing
, Hai Yan Zhang
, Mohamad Aljofan
, Alireza Mosavi Jarrahi
, Bolat Makabel
, Jian Ye Zhang

Department of Biomedical Sciences

Результат исследований › рецензирование

31 Цитирования (Scopus)

Аннотация

SARS-CoV-2 infection has become an urgent public health concern worldwide, severely affecting our society and economy due to the long incubation time and high prevalence. People spare no effort on the rapid development of vaccine and treatment all over the world. Amongst the numerous ways of tackling this pandemic, some approaches using extracellular vesicles (EVs) are emerging. In this review, we summarize current prevalence and pathogenesis of COVID-19, involving the combination of SARS-CoV-2 and virus receptor ACE2, endothelial dysfunction and micro thrombosis, together with cytokine storm. We also discuss the ongoing EVs-based strategies for the treatment of COVID-19, including mesenchymal stem cell (MSC)-EVs, drug-EVs, vaccine-EVs, platelet-EVs, and others. This manuscript provides the foundation for the development of targeted drugs and vaccines for SARS-CoV-2 infections.

Язык оригинала	English
Номер статьи	699929
Журнал	Frontiers in Molecular Biosciences
Том	8
DOI	https://doi.org/10.3389/fmolb.2021.699929
Состояние	Published - июл. 21 2021

ASJC Scopus subject areas

Biochemistry
Biochemistry, Genetics and Molecular Biology (miscellaneous)
Molecular Biology

ЦУР ООН

Работа этого автора способствует достижению следующих Целей устойчивого развития

Доступ к документу

10.3389/fmolb.2021.699929

The Potential Role of Extracellular Vesicles in COVID-19 Treatment Opportunity and Challenge 73635c3cFinal published version, 1,29 MB

Другие файлы и ссылки

Fingerprint

Подробные сведения о темах исследования «The Potential Role of Extracellular Vesicles in COVID-19 Treatment: Opportunity and Challenge». Вместе они формируют уникальный семантический отпечаток (fingerprint).

Цитировать

@article{f3e16a06880b4673bc8a7553d3709881,

title = "The Potential Role of Extracellular Vesicles in COVID-19 Treatment: Opportunity and Challenge",

abstract = "SARS-CoV-2 infection has become an urgent public health concern worldwide, severely affecting our society and economy due to the long incubation time and high prevalence. People spare no effort on the rapid development of vaccine and treatment all over the world. Amongst the numerous ways of tackling this pandemic, some approaches using extracellular vesicles (EVs) are emerging. In this review, we summarize current prevalence and pathogenesis of COVID-19, involving the combination of SARS-CoV-2 and virus receptor ACE2, endothelial dysfunction and micro thrombosis, together with cytokine storm. We also discuss the ongoing EVs-based strategies for the treatment of COVID-19, including mesenchymal stem cell (MSC)-EVs, drug-EVs, vaccine-EVs, platelet-EVs, and others. This manuscript provides the foundation for the development of targeted drugs and vaccines for SARS-CoV-2 infections.",

keywords = "ACE2, COVID-19, extracellular vesicles (EVs), immunomodulation, mesenchymal stem cell (MSC), SARS-CoV-2",

author = "Yan, \{Yan Yan\} and Zhou, \{Wen Min\} and Wang, \{Yu Qing\} and Guo, \{Qiao Ru\} and Zhao, \{Fu Xi\} and Zhu, \{Zhuang Yan\} and Xing, \{Yan Xia\} and Zhang, \{Hai Yan\} and Mohamad Aljofan and Jarrahi, \{Alireza Mosavi\} and Bolat Makabel and Zhang, \{Jian Ye\}",

note = "Funding Information: This work was supported by the National Natural Science Foundation of China (81902152, U1903126, 81773888 and 81903467), Open Founding of Key Laboratory Ethnomedicine Ministry of Education (KLEM-KF2019Y03), the Key Medical Science and Technology Project of Shanxi Province (2020 XM33-“Four Batches” of Science and Technology Medical Innovation Project of Shanxi Province), and the Fund of Shanxi Province Higher Education Technology Innovation Project (2019L0753). Publisher Copyright: {\textcopyright} Copyright {\textcopyright} 2021 Yan, Zhou, Wang, Guo, Zhao, Zhu, Xing, Zhang, Aljofan, Jarrahi, Makabel and Zhang.",

year = "2021",

month = jul,

day = "21",

doi = "10.3389/fmolb.2021.699929",

language = "English",

volume = "8",

journal = "Frontiers in Molecular Biosciences",

issn = "2296-889X",

publisher = "Frontiers Media S. A.",

}

TY - JOUR

T1 - The Potential Role of Extracellular Vesicles in COVID-19 Treatment

T2 - Opportunity and Challenge

AU - Yan, Yan Yan

AU - Zhou, Wen Min

AU - Wang, Yu Qing

AU - Guo, Qiao Ru

AU - Zhao, Fu Xi

AU - Zhu, Zhuang Yan

AU - Xing, Yan Xia

AU - Zhang, Hai Yan

AU - Aljofan, Mohamad

AU - Jarrahi, Alireza Mosavi

AU - Makabel, Bolat

AU - Zhang, Jian Ye

N1 - Funding Information: This work was supported by the National Natural Science Foundation of China (81902152, U1903126, 81773888 and 81903467), Open Founding of Key Laboratory Ethnomedicine Ministry of Education (KLEM-KF2019Y03), the Key Medical Science and Technology Project of Shanxi Province (2020 XM33-“Four Batches” of Science and Technology Medical Innovation Project of Shanxi Province), and the Fund of Shanxi Province Higher Education Technology Innovation Project (2019L0753). Publisher Copyright: © Copyright © 2021 Yan, Zhou, Wang, Guo, Zhao, Zhu, Xing, Zhang, Aljofan, Jarrahi, Makabel and Zhang.

PY - 2021/7/21

Y1 - 2021/7/21

N2 - SARS-CoV-2 infection has become an urgent public health concern worldwide, severely affecting our society and economy due to the long incubation time and high prevalence. People spare no effort on the rapid development of vaccine and treatment all over the world. Amongst the numerous ways of tackling this pandemic, some approaches using extracellular vesicles (EVs) are emerging. In this review, we summarize current prevalence and pathogenesis of COVID-19, involving the combination of SARS-CoV-2 and virus receptor ACE2, endothelial dysfunction and micro thrombosis, together with cytokine storm. We also discuss the ongoing EVs-based strategies for the treatment of COVID-19, including mesenchymal stem cell (MSC)-EVs, drug-EVs, vaccine-EVs, platelet-EVs, and others. This manuscript provides the foundation for the development of targeted drugs and vaccines for SARS-CoV-2 infections.

AB - SARS-CoV-2 infection has become an urgent public health concern worldwide, severely affecting our society and economy due to the long incubation time and high prevalence. People spare no effort on the rapid development of vaccine and treatment all over the world. Amongst the numerous ways of tackling this pandemic, some approaches using extracellular vesicles (EVs) are emerging. In this review, we summarize current prevalence and pathogenesis of COVID-19, involving the combination of SARS-CoV-2 and virus receptor ACE2, endothelial dysfunction and micro thrombosis, together with cytokine storm. We also discuss the ongoing EVs-based strategies for the treatment of COVID-19, including mesenchymal stem cell (MSC)-EVs, drug-EVs, vaccine-EVs, platelet-EVs, and others. This manuscript provides the foundation for the development of targeted drugs and vaccines for SARS-CoV-2 infections.

KW - ACE2

KW - COVID-19

KW - extracellular vesicles (EVs)

KW - immunomodulation

KW - mesenchymal stem cell (MSC)

KW - SARS-CoV-2

UR - https://www.scopus.com/pages/publications/85112673388

UR - https://www.scopus.com/pages/publications/85112673388#tab=citedBy

U2 - 10.3389/fmolb.2021.699929

DO - 10.3389/fmolb.2021.699929

M3 - Review article

AN - SCOPUS:85112673388

SN - 2296-889X

VL - 8

JO - Frontiers in Molecular Biosciences

JF - Frontiers in Molecular Biosciences

M1 - 699929

ER -