Usage of multiparameter flow cytometry to study microglia and macrophage heterogeneity in the central nervous system during neuroinflammation and neurodegeneration

Marina Dukhinova, Ekaterina Kopeikina, Eugene D. Ponomarev

Результат исследований

12 Цитирования (Scopus)

Аннотация

The resident macrophages of the central nervous system (CNS), also known as microglia, and blood-derived macrophages play an important role in the functional activity of the normal CNS, as well as in the development of neuroinflammation during various neurodegenerative disorders. Microglia and macrophages represent heterogeneous populations, which can modulate CNS environment and have different effects on neuronal regeneration. In this chapter, the main features of microglial and macrophage subsets and current methods for investigation of their heterogeneity will be discussed.

Язык оригиналаEnglish
Название основной публикацииMethods in Molecular Biology
ИздательHumana Press Inc.
Страницы167-177
Число страниц11
DOI
СостояниеPublished - 2018
Опубликовано для внешнего пользованияДа

Серия публикаций

НазваниеMethods in Molecular Biology
Том1745
ISSN (печатное издание)1064-3745

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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